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Anticancer Agents Med Chem ; 22(11): 2109-2115, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34561994

RESUMO

BACKGROUND: Investigating the effects of newly synthesized agents on various molecular mechanisms to understand their mechanism of action is an important step of pre-clinical screening. Benzimidazoles are composed of a unique fused benzene and imidazole ring and have attracted great attention due to their broad bioactivities, including antitumor. OBJECTIVE: In the current study, we reported the synthesis of novel benzimidazole derivatives and investigated the possible cytotoxic and anti-angiogenic effects on human prostate cancer and umbilical vein endothelial cells (HUVECs). METHODS: MTT assay was used to assess cell viability. A scratch assay was conducted to monitor the migration of cells. mRNA expression levels of VEGF, MMP-2, and MMP-9 were evaluated using qPCR. Changes in protein levels were evaluated by western blotting. RESULTS: Compound G1, having a chlorine moiety, showed a potent cytotoxic activity on both prostate cancer cells and HUVECs, and inhibited cell migration via decreasing the mRNA and protein levels of key angiogenesis-related molecules such as VEGF, MMP-2, and MMP-9. CONCLUSION: These results suggest that newly synthesized G1 may be a novel anti-angiogenic agent for prostate cancer treatment.


Assuntos
Antineoplásicos , Neoplasias da Próstata , Inibidores da Angiogênese/farmacologia , Antineoplásicos/farmacologia , Benzimidazóis/farmacologia , Movimento Celular , Células Endoteliais da Veia Umbilical Humana , Humanos , Masculino , Metaloproteinase 2 da Matriz/genética , Metaloproteinase 9 da Matriz/genética , Neoplasias da Próstata/tratamento farmacológico , RNA Mensageiro , Fator A de Crescimento do Endotélio Vascular/genética , Fator A de Crescimento do Endotélio Vascular/metabolismo , Fatores de Crescimento do Endotélio Vascular
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