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2.
Sci Rep ; 8(1): 17194, 2018 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-30446765

RESUMO

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

3.
Sci Rep ; 8(1): 14391, 2018 09 26.
Artigo em Inglês | MEDLINE | ID: mdl-30258106

RESUMO

Autophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing mRNA-sequencing data we found that in addition to the full-length ATG7 isoform, various tissues express a shorter isoform lacking an exon of 27 amino acids in the C-terminal part of the protein, termed ATG7(2). We further show that ATG7(2) does not bind LC3B and fails to mediate the lipidation of members of the LC3/GABARAP family. We have thus identified an isoform of ATG7 that is unable to carry out the best characterized function of the protein during the autophagic response. This short isoform will have to be taken into consideration when further studying the role of ATG7.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Proteína 7 Relacionada à Autofagia/metabolismo , Proteínas Associadas aos Microtúbulos/metabolismo , Sequência de Aminoácidos , Animais , Proteínas Reguladoras de Apoptose , Autofagia , Proteína 7 Relacionada à Autofagia/química , Células HEK293 , Humanos , Metabolismo dos Lipídeos , Camundongos , Modelos Moleculares , Ligação Proteica , Isoformas de Proteínas/química , Isoformas de Proteínas/metabolismo
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