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1.
Clin Exp Immunol ; 92(3): 397-403, 1993 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8099855

RESUMO

Thyroid sections from 18 consecutive euthyroid patients undergoing surgery for iodine deficiency goitre were investigated by means of immunohistochemistry and immunofluorescence, evaluating the expression of MHC class II antigens (HLA-DR, -DP, -DQ, and RFD1) and intercellular adhesion molecule-1 on the formerly described clusters of dendritic cells, as well as on thyrocytes. Eleven of 18 iodine deficiency goitres contained clusters of dendritic cells. These clusters appeared to express only HLA-DR in two cases; in nine of 12 cases they showed a differential expression of class II molecules in the following frequency: HLA-DR > DQ and/or -DP > RFD1. These dendritic cells also were ICAM-1+. In four of 18 iodine deficiency goitres, thyroid epithelial cells showed MHC class II expression in several combinations, but were ICAM-1-. In normal thyroids and in nodular goitres from inhabitants of the endemic area not having an actual iodine deficiency, only sparse clusters of dendritic cells were found; these cells were only HLA-DR+. Follicle lining cells were negative for the MHC class II molecules. In normal thyroids from an area with sufficient iodine supply, no clusters of dendritic cells were seen. The few dendritic cells observed were lying isolated in the interstitium and only positive for HLA-DR and ICAM-1; epithelial cells were negative for the studied markers. These data show clusters of dendritic cells in thyroids of inhabitants of an endemic area. When goitre is accompanied by iodine deficiency at the moment of operation, there appears to be activation of these dendritic cells and of thyroid epithelial cells.


Assuntos
Moléculas de Adesão Celular/imunologia , Células Dendríticas/imunologia , Bócio Endêmico/imunologia , Antígenos de Histocompatibilidade Classe II/imunologia , Iodo/deficiência , Glândula Tireoide/imunologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticorpos Monoclonais , Feminino , Imunofluorescência , Bócio Endêmico/cirurgia , Humanos , Técnicas Imunoenzimáticas , Molécula 1 de Adesão Intercelular , Masculino , Pessoa de Meia-Idade , Glândula Tireoide/patologia , Glândula Tireoide/cirurgia
2.
Thyroidology ; 4(1): 53-5, 1992 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-1284335

RESUMO

Iodine deficient goiters were studied by immunohistochemistry and showed extensive presence and typical arrangement of dendritic cells, known to have excellent antigen presenting capacity. These cells were positive for all MHC-class II epitopes and for ICAM-1. Epithelial follicle lining cells were also seen to be class II positive but lacked ICAM-1. Thyroglobulin seemed not to be iodinated at the C-terminal hormogenic site, as shown by reactions with monoclonal antibodies. Iodine therapy, as well as thyroxine therapy were effective in reducing thyroid size. Both forms of therapy were found to decrease the pretreatment levels of circulating thyroid growth stimulating immunoglobulins (TGI).


Assuntos
Bócio/imunologia , Sistema Imunitário/imunologia , Iodo/deficiência , Anticorpos Monoclonais/imunologia , Moléculas de Adesão Celular/imunologia , Dendritos/imunologia , Epitopos/imunologia , Imunofluorescência , Genes MHC da Classe II , Bócio/tratamento farmacológico , Bócio/patologia , Humanos , Imuno-Histoquímica , Iodo/uso terapêutico , Tireoglobulina/metabolismo
3.
Acta Med Austriaca ; 17 Suppl 1: 43, 1990.
Artigo em Inglês | MEDLINE | ID: mdl-2202180

RESUMO

This study describes dendritic cells in thyroid sections of iodine deficient goiters. Cells were characterized by monoclonal markers and detected by immunohistochemistry and double labelling immunofluorescence. We observed dendritic cells located in focal aggregates in the interstitium and epitheloid cells as well as multinucleated giant cells filling thyroid follicles. All these cells showed strong positivity for the MHC class II molecules HLA-DR, -DQ, -DP and RFD1, a monoclonal marker for active antigen presenting cells.


Assuntos
Células Dendríticas/imunologia , Células Epitelioides/imunologia , Células Gigantes/imunologia , Bócio Endêmico/imunologia , Iodo/deficiência , Células Apresentadoras de Antígenos/imunologia , Contagem de Células , Humanos , Técnicas Imunoenzimáticas , Glândula Tireoide/imunologia
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