Myxoid Liposarcoma Metastasizing to the Parotid Gland.

Myxoid liposarcoma (MLPS) of the parotid gland is very rare, and only a few cases have been reported worldwide. It can be difficult to diagnose this disease when there is only a single lesion in the patient's body. A 56-year-old man was diagnosed with an MLPS in the left calf and was treated with wide resection. Two months after the surgery, a painless mass appeared in the man's left parotid gland area. Both fine-needle aspiration biopsy before surgery and intraoperative frozen sections suggested that the tumor was likely to be a pleomorphic adenoma. Both parotid ultrasound and CT indicated the same result. However, this mass was confirmed to be metastasis of MLPS through immunohistochemistry and multicolor fluorescence in situ hybridization. The authors report a case in which an MLPS metastasized to the parotid gland; this type of lesion is extremely rare and highly worthy of consideration because the authors misdiagnosed it.

Investigating and improving the ecological efficiency of urban agglomeration based on Super-SBM model.

The management of ecological efficiency (eco-efficiency) is of great significance to promote the sustainable development of urban agglomerations. The objective of this research is to evaluate the eco-efficiency of urban agglomerations. Taking the Yangtze River Delta Urban Agglomeration (YRDUA) as a case study, this study evaluated the spatio-temporal evolution characteristics of the eco-efficiency by using the Super-SBM model. Additionally, the factors that affect the efficiency fluctuations are analyzed by decomposing the Global Malmquist-Luenberger (GML) index and the input-output redundancy rates are measured. The study additionally put forth a conceptual framework aimed at evaluating eco-efficiency within the context of urban agglomerations. The findings indicated that the eco-efficiency of the YRDUA had not reached the effective level with noticeable variations across different regions. The resource redundancy of the YRDUA was severe and negatively correlated with eco-efficiency. Environmental pollution was the primary cause of efficiency loss. Technological progress was the main driving factor of regional total factor productivity (TFP), but technical efficiency still needed to be improved. Therefore, it is urgent for the YRDUA to improve the efficiency of its industrial structure and foster the harmonious growth of various sectors, in order to achieve the sustainable utilization of natural resources and the preservation of the ecological environment.

Evaluating supply-demand matching of ecosystem services considering water-energy-food nexus and synergies/trade-offs in the Hangzhou of China.

The proposal of water-energy-food nexus provides a new perspective for the supply-demand matching assessment of ecosystem services (ESs). This study aims to evaluate quantitative and spatial matching of supply-demand of ESs considering water-energy-food nexus, and to analyze the synergies/trade-offs between ESs. By taking Hangzhou as a case study, the results showed that supply-demand matching degrees of ESs related to water-energy-food nexus in Hangzhou were all less than zero during the study period, indicating that the supply of ESs in Hangzhou could not meet the local demand. Among them, the gap between supply and demand of water yield gradually narrowed, while the gap between supply and demand of carbon storage/food production gradually widened. From the perspective of supply-demand spatial matching, water yield/food production was dominated by low-low spatial matching area, showing an expanding trend. Carbon storage was mainly characterized by high-low spatial mismatching area, presenting a stable trend. In addition, there were significant synergistic effects between ESs related to water-energy-food nexus. Therefore, this study proposed some supply-demand management policies of ESs from the perspective of water-energy-food nexus to promote the sustainable development of ecosystems and natural resources.

Impacts of land use/land cover changes on ecosystem services in ecologically fragile regions.

High-density human activities have rapidly changed the pattern of urban land use/land cover (LULC), affecting the supply of urban ecosystem services (ESs). This poses a challenge to the balance of urban development and ecological protection, which may be more serious in ecologically fragile regions. This study identified key LULC change (LULCC) impacts on ESs in Ordos, an ecologically fragile region in Northwest China. The urbanization process of Ordos will continue in 2030 under the business-as-usual scenario due to its strategic positioning in the National Energy Base of China. The future LULC simulation results showed that developed land in eastern Ordos will continue to expand in 2030, and more forest and grassland will appear in western Ordos as a result of ecological restoration. The results of the InVEST model in calculating four important ESs showed that the ES supply in the densely populated areas (eastern Ordos) has declined, and more attention must be given to natural vegetation protection in the urbanization process. Although carbon storage in the western region has increased due to afforestation, this also reduces the water yield supply, which may exacerbate the water shortage in Ordos. Supported by this framework, more sustainable urban land use management can be undertaken to balance the conflict between ecological protection and urbanization. This will contribute to regional ecological health and sustainable urban development.

Optimization of Regional Water-Energy-Food Systems Based on Interval Number Multi-Objective Programming: A Case Study of Ordos, China.

Water, energy, and food are the most important basic resources for economic and social development. In the context of global population growth, environmental degradation, and resource shortages, the interrelationship between the water, energy, and food has become increasingly important. In this paper, the city of Ordos in China was selected as a study area. Firstly, this paper sorted out relevant research literature and fully understood the concept of water-energy-food (WEF) nexus. Then, an optimization model of WEF system was constructed based on interval number multi-objective programming, which took the comprehensive coordination deviation degree of the WEF system security and carbon dioxide emission minimization as the target. At the same time, the optimization model was constructed with full consideration of constraints such as economic benefit, water resource consumption, energy production, food production and environmental pollution emission. The results showed that the production of coal, thermal power, hydropower, wind power, and food all show an upward trend. Among them, the production of hydropower has the largest change, and the food production has the smallest change. In terms of water resource utilization, food production has the largest allocation of water resources accounting for nearly 80%, followed by coal production, thermal power generation and hydropower generation. The smallest allocation is natural gas. In particular, the allocation of water for coal production and hydroelectric power generation has increased significantly. Finally, the policy recommendations were put forward to promote the sustainable development of WEF system in Ordos. The optimization research on the WEF system can help to ensure the WEF system security in Ordos and promote the sustainable development of WEF system, which also can provide reference for other regions.

Multi-Objective Optimization of a Regional Water-Energy-Food System Considering Environmental Constraints: A Case Study of Inner Mongolia, China.

Water, energy, and food, as the basic material resources of human production and life, play a prominent role in social and economic development. As the imbalance between the supply and demand of water, energy, and food increases, a highly sensitive and fragile relationship gradually forms among water, energy, and food. In this paper, Inner Mongolia in China is selected as a research area. Firstly, synergy theory is applied to establish the framework of a water-energy-food system. Then, a multi-objective programming model is constructed, where the objective functions are defined to minimize the integrated deviation degree and pollutant emissions of the water-energy-food system. Meanwhile, maximization of the water benefit, energy production, and food production is also considered. In addition, the model takes economy, environment, water, energy, and food as constraints. Finally, a genetic algorithm is designed for accurately assessing the most promising results. The results show that the cooperation degree of the water-energy-food system in Inner Mongolia is getting better and better, and the pollutant emission from the water-energy-food system is decreasing. In 2020, the proportion of agricultural water consumption fell by 1%, while that of industrial water consumption rose by 0.48%. The production of coal, natural gas, and power are all showing an increasing trend. Among them, the increase of natural gas production is as high as 38,947,730 tons of standard coal. However, the proportions of coal, natural gas, and power change inconsistently, where the proportions of coal and natural gas increase while that of power decreases. Corn production accounts for more than 80% of the total, which is in the eldest brother position in the food industry structure. Besides, there are differences between the planned values and optimal values of decision variables. Finally, suggestions are put forward to improve the sustainable development of water-energy-food in Inner Mongolia.

What is noise-induced hearing loss?

Noise-induced hearing loss is sensory deafness caused by long-term exposure of the auditory system to a noisy environment. Auditory fatigue is an early symptom of noise-induced hearing loss, and hearing can gradually recover after people leave a noisy environment. However, if people remain in a noisy environment for a prolonged period of time, their hearing will be permanently impaired. Societal changes mean that people are more likely to be exposed to noise. The hearing loss and tinnitus caused by noise seriously affect people's quality of life and lead to huge economic loss. The pathogenesis of noise-induced hearing loss is complex. Various theories try to explain this, such as the oxidative stress theory, but none perfectly explains the occurrence of noise-induced hearing loss. There is no treatment which can completely reverse the damage. More research is required to explore the pathogenesis and to better guide clinical practice. Preventative strategies, such as educating the public about hearing health, should be adopted to reduce the harm of noise-induced hearing loss.

Research on Total Factor Productivity and Influential Factors of the Regional Water-Energy-Food Nexus: A Case Study on Inner Mongolia, China.

With the supply of water, energy and food facing severe challenges, there has been an increased recognition of the importance of studying the regional water-energy-food nexus. In this paper, Inner Mongolia, including 12 cities in China, was selected as a research case. A super-efficiency slack based measure (SBM) model that considered the undesirable outputs was adopted to calculate the regional total factor productivity (TFP) and the Malmquist-Luenberger index was used to investigate the change trend of the TFP from 2007 to 2016 based on understanding the water-energy-food nexus. Finally, influential factors of the TFP were explored by Tobit regression. The results show that the 12 Inner Mongolia cities are divided into higher, moderate and lower efficiency zones. The higher efficiency zone includes Ordos, Hohhot, Xing'an, and Tongliao, and the lower efficiency zone includes Chifeng, Xilin Gol, Baynnur, Wuhai and Alxa. There is a serious difference in TFP between Inner Mongolia cities. During the study period, the TFP of the water-energy-food nexus in Inner Mongolia cities shows a rising trend, which is mainly driven by the growth of technical progress change. However, the average ML values of the lower and moderate efficiency zones were inferior to the higher efficiency zone in six of the ten years, so the difference between Inner Mongolia cities is growing. According to the Tobit regression, the mechanization level and degree of opening up have positive effects on the TFP, while enterprise scale and the output of the third industry have negative effects on the TFP. Government support does not have any significant impact on the TFP. Finally, suggestions were put forward to improve the TFP of the water-energy-food nexus in Inner Mongolia cities.

Different patterns of endocytosis in cochlear inner and outer hair cells of mice.

Precise and efficient endocytosis is critical for sustained neurotransmission during continuous neuronal activity. Endocytosis is a prerequisite for maintaining the auditory function. However, the differences between the patterns of endocytosis in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) remain unclear. Both IHCs and OHCs were obtained from adult C57 mice. Patterns of endocytosis in cells were estimated by analyzing the uptake of FM1-43, a fluorescent. The observations were made using live confocal imaging, fluorescence intensities were calculated statistically. Results revealed the details about following phenomenon, i) sites of entry: the FM1-43 dye was found to enter IHC at the apical area initially, the additional sites of entry were then found at basolateral membrane of the cells, The entry of the dye into OHCs initially appeared to be occurring around whole apical membranes area, which then diffused towards the other membrane surface of the cells, ii) capacity of endocytosis: fluorescence intensity in IHCs showed significantly higher than that of OHCs (P<0.01). We have found different patterns of endocytosis between IHCs and OHCs, this indicated functional distinctions between them. Moreover, FM1-43 dye can be potentially used as an indicator of the functional loss or repair of cochlear hair cells.

Maximal number of pre-synaptic ribbons are formed in cochlear region corresponding to middle frequency in mice.

OBJECTIVE: To investigate whether there are more quantitative pre-synaptic ribbons formed in the cochlear region corresponding to middle-frequency in cochlea of mice. METHODS: Counts of pre-synaptic ribbons were performed using immunostaining and laser confocal microscopy. Hearing thresholds and function of ribbon synapses were estimated by auditory brain response (ABR) and compound action potential (CAP). Cochlear mapping has been achieved to match the frequencies and corresponding regions along the cochlear spiral. RESULTS: The number of pre-synaptic ribbons in per inner hair cell (IHC) has been found to increase gradually from the base turn, the maximal quantity appeared at the region of 50-70% from the apex. Next, ABR thresholds showed that there was the lowest ABR threshold in the frequency around 8-16 kHz, corresponding to the region of 50-70% from the apex according to the cochlear mapping. Further, CAP amplitudes were estimated, and the maximal value identified at the same frequency (8-16 kHz). CONCLUSIONS: Maximal number of pre-synaptic ribbons is formed in the cochlear region of middle frequency in mice, coupling with the lowest ABR threshold and highest CAP amplitudes. Our study shows that the middle frequency (8-16 kHz) could be the most sensitive region to sound stimuli in mice.