Design and simulation of a secondary resource recycling system: A case study of lead-acid batteries.

The recycling of secondary resources is complicated as consumers, recyclers and governments are all involved in this process. In developing countries, compared to legal recyclers, illegal recyclers not only have cost advantages but also create serious pollution. Inappropriate management policies may cause disorder in the recycling market or inefficient fiscal management. This paper takes China's lead-acid batteries (LABs) from 2000 to 2015 as an example to construct a model of a secondary resource recovery system based on heterogeneous groups and analyzes the environmental and economic impacts of used LAB recycling. By simulating the implementation of different tax cuts, subsidies and regulatory policies by the government in each year, we observe the overall environmental impact of the recycling industry. This study finds that when the total amount of government expenditures is limited, the optimal policy combination emphasizes tax reduction and subsidy policies during the growth period of the recycling industry and uses more funds for supervision in the mature period. Under the balance of fiscal revenues and expenditures, the optimal policy combination can reduce the number of illegal recycling companies and waste lead emissions from the recycling market by 97.9% and 45.8%, respectively. Compared to research conducted using mathematical models and system dynamics models, this result is more in line with the actual situation, and the content is more intuitive. The government needs to adopt different policy combinations in different periods according to the state of the recycling market so that the recycling of secondary resources can achieve the optimal effect.

Platelet and peripheral white blood cell counts at diagnosis predict the response of adult immune thrombocytopenia to recombinant human interleukin-11: A retrospective, single-center, case-control study.

This study evaluated the effectiveness of recombinant human interleukin-11 (rhIL-11) in the treatment of immune thrombocytopenia (ITP) and determined whether clinical and laboratory findings predicted the treatment response.This retrospective, single-center, case-control study included 103 adult patients with ITP treated between July 2010 and April 2014 at Jiangxi Province People's Hospital. About 49 patients in the pred+IL group received prednisone (conventional dose) combined with an rhIL-11 regimen, and 54 patients in the pred alone group received prednisone (conventional dose) alone. Demographic data, initial and follow-up platelet counts, proportions of patients achieving platelet counts ≥30 × 10/L (response) and ≥100 × 10/L (complete response) at different time points, and adverse reactions were compared between groups.Complete response rates were similar between groups overall but higher in the pred+IL group than in the pred alone group for newly diagnosed patients and those with severe ITP (P < .05). Proportions of patients achieving response or complete response at different time points were similar between groups overall but higher in the pred+IL group than in the pred alone group for newly diagnosed patients and those with severe ITP (P < .05). Posttreatment platelet count correlated negatively with platelet count at diagnosis and white blood cell (WBC) count at diagnosis in patients with newly diagnosed ITP (r = -0.337, P = .073 and r = -0.367, P = .050, respectively) or ITP with bleeding-related episodes (r = -0.357, P = .020 and r = -0.434, P = .004, respectively). No immediate or postinfusion severe adverse reactions were observed.rhIL-11 increased CR and improved hemostasis in patients with newly diagnosed or severe ITP. Platelet and WBC counts at diagnosis can predict the response to rhIL-11.

[FLK-1+ cells derived from mouse fetal liver could differentiate into endothelial cells and smooth muscle cells].

OBJECTIVE: To characterize the differential and proliferative activities of FLK-1(+) cells derived from mouse fetal liver. METHOD: The FLK-1(+) fraction were enriched from the fetal liver using immunomagnetic method and their differential and proliferative activities were examined in culture medium and in vivo via transplantation of FLK-1(+) cells into the inferior pole of the spleen of nine-week-old male C57 BL/6 mice after two-thirds hepatectomy. RESULTS: In response to growth factors, FLK-1(+) cells expressed typical lineage-specific markers for vascular endothelial cells, smooth muscle cells. Intrahepatic implantation of FLK-1(+) cells resulted in the formation of blood vessels in the fibrous capsule of partially hepatectomized liver. CONCLUSION: These results indicate that FLK-1(+) cells derived from mouse fetal liver could differentiate into endothelial cells and smooth muscle cells and they may serve as potential stem cells for clinical cell-based therapy.