RESUMO
AIM: To investigate the effect of acute exhaustive exercise on gastrointestinal motility and its enteric nervous mechanisms. METHODS: 24 rats were randomly divided into control group (C) and acute exhaustive exercise group (AEE). The rate of gastrointestinal transit was measured and histologic changes of nitriergic nerves in ileum myenteric plexus were observed with enzymatic histochemical and image analytic technique. RESULTS: In the rats of AEE group, the rate of gastrointestinal transit was delayed comparing with C group (P < 0.05), the numbers of nitrergic neurons and expression levels of nitric oxide synthase (NOS) in the ileum myenteric plexus significantly increased comparing with C group (P < 0.01). CONCLUSION: It is possible that increase of nitrergic neurons and expression levels of NOS in the myenteric plexus of small intestine are one of the mechanisms of delay of gastrointestinal transit rate in acute exhaustive exercise rats.
Assuntos
Motilidade Gastrointestinal/fisiologia , Trânsito Gastrointestinal/fisiologia , Íleo/inervação , Atividade Motora , Plexo Mientérico , Neurônios Nitrérgicos/citologia , Animais , Masculino , Plexo Mientérico/metabolismo , Óxido Nítrico Sintase/metabolismo , Ratos , Ratos Sprague-DawleyRESUMO
OBJECTIVE: To study the chemical constituents of the leaves of Cassia angustifolia Vahl. METHODS: Solvents extraction and various chromatographic methods were applied to separate and purify its constituents. The structures were elucidated on the basis of chemical evidence and spectral analysis. RESULTS: Six compounds were obtained and identified as cholesterol (I), kampferol-3-rutinoside (II), calyxanthone (III), 3-methoxy-4-hydroxy-benzoic acid (IV), p-dimethylaminobenzaldehyde (V), 3,4-dihydroxybenzoic acid (VI). CONCLUSION: Six compounds ( I -VI) are obtained from this plant for the first time.
Assuntos
Benzaldeídos/isolamento & purificação , Colesterol/isolamento & purificação , Plantas Medicinais/química , Senna/química , Benzaldeídos/química , China , Colesterol/química , Cromatografia em Camada Fina/métodos , Hidroxibenzoatos/química , Hidroxibenzoatos/isolamento & purificação , Estrutura Molecular , Folhas de Planta/químicaRESUMO
AIM: To study the synthesis and antibacterial activity of ciprofloxacin derivatives. METHODS: Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested. RESULTS: Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis. CONCLUSION: Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.
