RESUMO
A study was carried out in 10 healthy volunteers, aged between 22 and 28 years, to investigate the pharmacokinetics of an aspirin-metoclopramide combined preparation compared with those of the individual components given alone. Blood levels were determined before and after administration of a single dose of the three medications given at weekly intervals. No significant difference was found in the bioavailability of either the aspirin or metoclopramide from the combination as compared to the individual components.
Assuntos
Aspirina/metabolismo , Metoclopramida/metabolismo , Administração Oral , Adulto , Aspirina/sangue , Disponibilidade Biológica , Cromatografia Líquida de Alta Pressão , Combinação de Medicamentos/sangue , Combinação de Medicamentos/metabolismo , Feminino , Humanos , Cinética , Masculino , Metoclopramida/sangueRESUMO
Highly buffered acetylsalicylate was used to treat diarrhoea and other gastrointestinal side-effects of radiotherapy in 28 women who were receiving treatment for uterine cancer. In a double-blind, balanced, and randomised trial, acetylsalicylate significantly reduced the number of bowel motions and relieved abdominal pain and flatulence.
