RESUMO
Exciting new discoveries into the pathophysiological mechanisms of immunologic and inflammatory ocular disease continue. The genetic locus for susceptibility to Behçet's disease and Sjögrens syndrome has been further characterized. Important guidelines for serial slit-lamp examinations for the early detection of iridocyclitis in juvenile rheumatoid arthritis is suggested. In ocular allergy, further investigation of the interaction between mast cell and eosinophil sheds more light on the pathophysiological mechanism of vernal keratoconjunctivitis and vernal corneal ulcers. Unusual manifestations of Behçet's disease, sarcoidosis, scleritis, and Wegener's granulomatosis are reported. A possible pathophysiological mechanism for lacrimal gland destruction in Sjögrens syndrome is presented.
Assuntos
Oftalmopatias/diagnóstico , Doenças do Sistema Imunitário/diagnóstico , Doenças Reumáticas/diagnóstico , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/fisiopatologia , Artrite Reumatoide/terapia , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/fisiopatologia , Síndrome de Behçet/terapia , Oftalmopatias/fisiopatologia , Oftalmopatias/terapia , Granulomatose com Poliangiite/diagnóstico , Granulomatose com Poliangiite/fisiopatologia , Granulomatose com Poliangiite/terapia , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/fisiopatologia , Hipersensibilidade/terapia , Doenças do Sistema Imunitário/fisiopatologia , Doenças do Sistema Imunitário/terapia , Doenças Reumáticas/fisiopatologia , Doenças Reumáticas/terapia , Sarcoidose/diagnóstico , Sarcoidose/fisiopatologia , Sarcoidose/terapia , Esclerite/diagnóstico , Esclerite/fisiopatologia , Esclerite/terapia , Síndrome de Sjogren/diagnóstico , Síndrome de Sjogren/fisiopatologia , Síndrome de Sjogren/terapiaRESUMO
Metastatic disease to the optic nerve is uncommon. Optic nerve involvement has been described as an extension from choroidal, retinal, orbital, or central nervous system metastatic foci. Isolated optic nerve metastatic disease is extremely rare. We present the case of an isolated circumscribed metastatic lesion to the retrobulbar portion of the optic nerve detected radiographically.
