Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives.

BACKGROUND: The disruptions in skin integrity contribute to its disorientation, and tissue annihilations result in acute or chronic wound formation. Polyherbal formulations are widely used in traditional systems of mecdicine like ayurveda for wound healing. The combination of these traditional therapies with clinical therapies has helped in the development of various wound-healing products. METHOD: In this systematic review, the therapeutic potency of several polyherbal formulations from different medicinal floras is summed together in response to their impact on wound healing. The literature search was performed on Pubmed, Scopus, and ScienceDirect databases between 2010-2020. PRISMA methodology was applied to extract relevant information about polyherbal formulations. RESULT: A total of 54 articles were selected under all themes for the data extraction as per the PRISMA guidelines. These 54 articles have high-quality scores ≥3. Forty-three records were used for the narrative analysis, while nine records were used for the critical analysis in the narrative review. Further, theme-wise key data sets were screened from the selected literature and summarized in a tabular form. Bibliometric analysis of the Scopus database has also drawn attention to limited academic literature showcasing randomized clinical trials in the current subject. Most of these polyherbal formulations are tested in laboratory-scale studies, thus portraying further research options. CONCLUSION: Polyherbal formulations are effective in promoting the wound-healing process. They can stimulate a variety of physiological functions that accelerates the process of healing. These formulations merit further investigation in clinical trials, and production up scaling will aid in the creation of a new horizon of polyherbal wound healing products.

Current Challenges for the Effective Management of the COVID-19 Pandemic.

INTRODUCTION: Within a short period, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) spread all over the globe and became the first pandemic of the present century. Early diagnostic tools and effective drugs are urgently needed to effectively manage the COVID-19 pandemic. Based on current literature, we provide recent updates on SARS-CoV-2 biology, available diagnostic methods, and therapeutic options for the management of COVID-19 pandemic. METHODS: A literature survey was done using Google and PubMed and Web of Science to summarize the current updates on this topic. RESULTS: Current coronavirus diagnostic tests are reverse transcription polymerase chain reaction (RT-PCR), real-time RT-PCR (qRT-PCR), and reverse transcription loop-mediated isothermal amplification (RT-LAMP) which detects the presence of specific genome sequence of virus. Existing antiviral drugs or new therapeutic options such as neutralizing antibody or plasma therapy are mostly used to restrict the virus growth with a limited success. CONCLUSION: As there is no specific treatment or vaccine available to limit the infection of SARS-CoV-2, we need to rely on the existing way to limit the disease. The first priority to fight COVID-19 is development of early diagnostic tools so that infected persons can be identified and further viral transmission can be blocked. Evaluation of existing drugs or identification of new therapeutic entities becomes the major challenge to deal with the present pandemic.

The impact of anthropogenic organic and inorganic pollutants on the Hasdeo River Water Quality in Korba Region, Chhattisgarh, India.

In the name of development, industries discharge their wastewater, which contains different Metallic species and massive organic load into the next-door river system. In this study, we assess the impact of organic and inorganic contaminations on Hasdeo River at Korba region, which is fifth critically polluted city in India. Hear, a new approach for water quality indexing like Water quality index (WQI), Heavy metal pollution index (HPI) and metal index (MI) has been proposed to represent pollution due to heavy metals in river system. The sample's pollution parameters and heavy metals contamination is exceed from BIS or WHO standards of drinking water (all p<0.05). WQI shows that the entire water samples are not suitable for drinking and aquatic life but they are safe only for irrigation. HPI and MI calculation revels that more than 95% sampling sites are critically polluted with heavy metals. Thus, a high level of industrialization deterioration of river water quality is recorded for adequate action.

A comparative study of antibacterial and antifungal activities of extracts from four indigenous plants.

A repetitive and wide use of chemical antibiotics has brought a serious threat in the biomedical and clinical sectors by the emergence of multidrug resistant pathogens. Plants have secondary metabolites that make them suitable candidate for natural antimicrobial agent without any side effect. In this study, we assessed comparative antibacterial and antifungal effects of extracts from four Indigenous plants (Nerium sp; Mentha sp; Aloe vera and Eucalyptus sp). Total phenolic and flavonoid content were extracted by microwave-assisted extractor and used for phytochemical assay. Antimicrobial experiment was done by micro dilution technique. A post hoc analysis inbuilt with one-way ANOVA test was used for the compilation of antibiotic sensitivity data and percent inhibition. Total phenolic content was significantly high in Mentha sp. and low in Nerium sp. (All p < 0.05). In antibacterial and antifungal activity higher concentrations of extracts showed a strong activity, which was as good as antibiotics used as control. Results from Eucalyptus sample showed a significant growth reducing capability even at lower concentrations. This study concludes that the plant extracts can be used to treat microbial infections with almost same efficacy as antibiotics and with a lower chance of resistance development.