[Intracellular disorders in the dog myocardium in low cardiac output syndrome caused by massive hemorrhage, approaches to correction]. / Vnutrikletochnye narusheniia v miokarde u sobak pri sindrome malogo serdechnego vybrosa, vyzvannom massivnoi krovopoterei, puti korrektsii.

It was shown on dog experiments that disorders in the phosphorylation-proteolysis-calcium transport system in the sarcoplasmatic reticulum of pathologically changed myocardium are an important component of cardiac activity depression in massive blood loss. Low cardiac output can be corrected by ammonium molibdate, phosphoprotein phosphatase inhibitor, and contrycal, proteolysis inhibitor.

[Thyroid hormones and melatonin as means of antioxidant therapy]. / Tireoidnye gormony i melatonin kak sredstva antioksidantnoi terapii.

The possibility of involvement of thyroid hormones and melatonin in cell protection from damage by active oxygen forms (hydroxyperoxide, superoxide radical, and hypochlorite) was investigated. The intensity of inhibition of luminol-dependent chemiluminescence induced by neutrophils and active oxygen forms in the presence of hormones was evaluated. Antioxidant activities of the enzymes were compared with that of glutathione. Probable mechanisms of antioxidant effect of the studied hormones are discussed.