RESUMO
Cocaine causes serious neurologic and neuropsychiatric complications. Cocaine-induced seizures are common and appear to be due to the local anaesthetic actions of this compound. Cocaine induced stroke has varied mechanisms. With ischemic stroke there is severe vasospasm induced by rises in brain catecholamines. These changes can persist for many weeks and can be demonstrated using single-photon emission computerized tomography (SPECT). In many patients with psychiatric symptoms such as psychosis or mania, SPECT demonstrates similar changes in cerebral blood flow. In fact, some of the psychiatric symptoms induced by cocaine may be due to decreases in cerebral blood flow. In cocaine abuse, treatment strategies based on decreasing cerebral vasospasm need to be developed.
Assuntos
Encéfalo/efeitos dos fármacos , Cocaína/efeitos adversos , Psicoses Induzidas por Substâncias , Tomografia Computadorizada de Emissão de Fóton Único , Transtorno Bipolar/induzido quimicamente , Encéfalo/patologia , Encéfalo/fisiopatologia , Catecolaminas/análise , Catecolaminas/farmacocinética , Transtornos Cerebrovasculares/induzido quimicamente , Feminino , Humanos , Masculino , Convulsões/induzido quimicamenteRESUMO
A 35 year old married male who had previously had manic episodes twice, during winter months, was treated with intermittent lithium therapy between November and February of each year and was well for a period of five years. The case report and the findings are discussed to demonstrate the possibility of intermittent lithium therapy in some patients.
Assuntos
Transtorno Bipolar/tratamento farmacológico , Lítio/administração & dosagem , Adulto , Transtorno Bipolar/psicologia , Diarreia/induzido quimicamente , Relação Dose-Resposta a Droga , Esquema de Medicação , Humanos , Lítio/efeitos adversos , Carbonato de Lítio , Masculino , Estações do AnoRESUMO
A young male presented both Capgras syndrome and Folie à Deux. Both of his parents shared the same delusions with the patient. A dynamic explanation is provided for the simultaneous occurrence of both syndromes. The case report and the management of this patient may be of interest to clinicians.
Assuntos
Síndrome de Capgras/complicações , Transtornos Psicóticos/complicações , Transtorno Paranoide Compartilhado/complicações , Adulto , Síndrome de Capgras/psicologia , Humanos , Masculino , Transtornos Neurocognitivos/complicações , Relações Pais-Filho , Transtorno Paranoide Compartilhado/psicologiaRESUMO
Three acutely psychotic patients with psychomotor excitement and agitation were rapidly sedated following intramuscular injections of 2.5 mg to 3 mg of midazolam. The use of midazolam, a short- and rapid-acting benzodiazepine preparation, in a psychiatric emergency room setting is discussed.
