RESUMO
Effect of heteroligands (L) on the properties of vanadium peroxides was investigated by preparing a number of peroxovanadium complexes, which were characterized by analysis, IR, UV/V and NMR spectra. X-ray structures for some were obtained. The vanadates(V) contain the cation M(I) = Na, K, NH4, Rb or Cs. Diperoxo complexes include M(I)[VO(O2)2 L], where L = dipyridyl, o-phenanthroline; M(I)3[VO(O2)2(C2O4)]; K2[(nicotinic acid)[VO(O2)2]2]H2O;M(I)4[O[VO(O2)2]2cystine]2H2O; H4[O[VO(O2)2(adenine)2)2]2H2O; and K2H2[O[VO(O2)2(adenosine)]2] 2H2O. Monoperoxo vanadates(V) correspond to the formula M(I)2[VO(O2)L]2 for L = citrate and malate; M(I)2[VO(O2)L] for L = nitrilotriacetate; M(I)[VO(O2)L] for L = iminodiacetate, tartrate and EDTA; and [HVO2(O2)(adenosine)]2H2O. Syntheses of these heteroligand peroxovanadium compounds are sensitive to pH, temperature and the concentration of the components. The stability towards decomposition in solid state, mother-liquid and pure water solutions depends upon the heteroligand. Characteristic (V = O) and (O-O) stretching frequency bands in IR can be correlated with the corresponding bond lengths and the [peroxo approximately V(V)] charge transfer bands in UV/V spectra. Intramolecular one-electron transfer in peroxo vanadates(V) can trigger the generation of radicals, and its dependency upon the nature of the heteroligand is discussed.
Assuntos
Vanadatos/síntese química , Cristalografia por Raios X , Ligantes , Estrutura Molecular , Vanadatos/químicaAssuntos
Antineoplásicos/uso terapêutico , Compostos de Vanádio/uso terapêutico , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Antineoplásicos/toxicidade , Poluentes Ambientais/toxicidade , Radicais Livres , Humanos , Camundongos , Oxirredução , Ratos , Compostos de Vanádio/química , Compostos de Vanádio/farmacologia , Compostos de Vanádio/toxicidadeRESUMO
A selected set of 14 V(V) complexes was tested for toxicity and antitumor activity against L1210 murine leukemia, to examine the biological properties of peroxoheteroligand vanadates(V) of the formula (NH4)4[O(VO(O2)2)2], M3I[VO(O2)2C2O4], and MI[VO(O2)L], L = malate, citrate, iminodiacetate, nitrilotriacetate, and EDTA. The x-ray structure is known for five of these compounds. A relationship has been found between the chemical composition and the biological activity (antitumor activity-toxicity) of these complexes. Activity in the L1210 system is defined as greater than or equal to 25% increase in life span, and this was seen with (NH4)4[O(VO(O2)2)2]; M3[VO(O2)2(C2O4)]2H2O, M = K, NH4; and NH4[VO(O2)Malato]H2O. These observations are important for the biochemistry of vanadium. The special nature of electron transfer within the V(V)-peroxo moiety is proposed to be responsible for this phenomenon. Peroxo heteroligand vanadates(V) therefore represent a model system for studying some biochemical interactions of vanadium in living matter.