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1.
Rev Neurol (Paris) ; 177(8): 1011-1012, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34215430
2.
Sci Rep ; 10(1): 6919, 2020 04 24.
Artigo em Inglês | MEDLINE | ID: mdl-32332814

RESUMO

To accelerate the cardiac drug discovery pipeline, we set out to develop a platform that would be capable of quantifying tissue-level functions such as contractile force and be amenable to standard multiwell-plate manipulations. We report a 96-well-based array of 3D human pluripotent stem cell (hPSC)-derived cardiac microtissues - termed Cardiac MicroRings (CaMiRi) - in custom 3D-print-molded multiwell plates capable of contractile force measurement. Within each well, two elastomeric microcantilevers are situated above a circumferential ramp. The wells are seeded with cell-laden collagen, which, in response to the gradual slope of the circumferential ramp, self-organizes around tip-gated microcantilevers to form contracting CaMiRi. The contractile force exerted by the CaMiRi is measured and calculated using the deflection of the cantilevers. Platform responses were robust and comparable across wells, and we used it to determine an optimal tissue formulation. We validated the contractile force response of CaMiRi using selected cardiotropic compounds with known effects. Additionally, we developed automated protocols for CaMiRi seeding, image acquisition, and analysis to enable the measurement of contractile force with increased throughput. The unique tissue fabrication properties of the platform, and the consequent effects on tissue function, were demonstrated upon adding hPSC-derived epicardial cells to the system. This platform represents an open-source contractile force screening system useful for drug screening and tissue engineering applications.


Assuntos
Células-Tronco Pluripotentes/citologia , Engenharia Tecidual/métodos , Animais , Automação , Cardiotônicos/farmacologia , Células Cultivadas , Coração/efeitos dos fármacos , Coração/fisiologia , Humanos , Camundongos , Contração Miocárdica/efeitos dos fármacos , Células-Tronco Pluripotentes/efeitos dos fármacos , Impressão Tridimensional
3.
Nutr Clin Pract ; 33(5): 594-596, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30208264

RESUMO

Parenteral nutrition (PN) is a complex therapeutic modality provided to neonates, children, and adults for various indications. Surveys have shown that current electronic health record (EHR) systems are in need of functionality enhancement for safe and optimal delivery of PN. This is a consensus statement from the American Society for Parenteral and Enteral Nutrition, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists outlining some of the key challenges to prescribing, order review/verification, compounding, and administration of PN using EHRs today and is a call to action for clinicians and vendors to optimize their EHRs regarding the PN build and workflow.

4.
Am J Health Syst Pharm ; 75(18): 1400-1420, 2018 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-30065062

RESUMO

Parenteral nutrition (PN) is a complex therapeutic modality provided to neonates, children, and adults for various indications. Surveys have shown that current electronic health record (EHR) systems are in need of functionality enhancement for safe and optimal delivery of PN. This is a consensus statement from the American Society for Parenteral and Enteral Nutrition, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists outlining some of the key challenges to prescribing, order review/verification, compounding, and administration of PN using EHRs today and is a call to action for clinicians and vendors to optimize their EHRs regarding the PN build and workflow.


Assuntos
Registros Eletrônicos de Saúde , Nutrição Parenteral/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Consenso , Humanos , Lactente , Recém-Nascido , Informática , Erros de Medicação/prevenção & controle , Soluções de Nutrição Parenteral , Nutrição Parenteral no Domicílio , Segurança do Paciente , Fluxo de Trabalho , Adulto Jovem
5.
J Acad Nutr Diet ; 118(8): 1506-1525, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-30055713

RESUMO

Parenteral nutrition (PN) is a complex therapeutic modality provided to neonates, children, and adults for various indications. Surveys have shown that current electronic health record (EHR) systems are in need of functionality enhancement for safe and optimal delivery of PN. This is a consensus statement from the American Society for Parenteral and Enteral Nutrition, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists outlining some of the key challenges to prescribing, order review/verification, compounding, and administration of PN using EHRs today and is a call to action for clinicians and vendors to optimize their EHRs regarding the PN build and workflow.


Assuntos
Dietética/normas , Registros Eletrônicos de Saúde/normas , Nutrição Parenteral/normas , Fluxo de Trabalho , Adulto , Criança , Consenso , Dietética/métodos , Feminino , Humanos , Recém-Nascido , Masculino
6.
Nutr Clin Pract ; 33(5): e1-e21, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30043492

RESUMO

Parenteral nutrition (PN) is a complex therapeutic modality provided to neonates, children, and adults for various indications. Surveys have shown that current electronic health record (EHR) systems are in need of functionality enhancement for safe and optimal delivery of PN. This is a consensus statement from the American Society for Parenteral and Enteral Nutrition, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists outlining some of the key challenges to prescribing, order review/verification, compounding, and administration of PN using EHRs today and is a call to action for clinicians and vendors to optimize their EHRs regarding the PN build and workflow.


Assuntos
Registros Eletrônicos de Saúde , Nutrição Parenteral , Fluxo de Trabalho , Adulto , Criança , Consenso , Dietética , Nutrição Enteral , Humanos , Recém-Nascido , Estado Nutricional , Farmácia , Prescrições , Sociedades , Estados Unidos
7.
Am J Cardiol ; 120(8): 1223-1229, 2017 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-28822562

RESUMO

Given the proven effectiveness of several cardiac medications for patients with coronary artery disease (CAD), we examined the national use of 4 classes of effective medications, overall and by age, sex, and race/ethnicity in 2005 to 2014. We used data from the National Health and Nutrition Examination Survey, including a self-reported diagnosis of CAD and independently verified medication use. Weighting procedures extrapolated our data to the adult US population with CAD. Analyses included 1,789 US adults aged ≥45 years with a history of CAD. The average age of this population was 68 years; 40% were women and 79% were non-Hispanic whites. In 2005 to 2014, 53.2% (standard error [SE] = 1.5) reported use of angiotensin-converting enzyme inhibitor/angiotensin receptor blockers, 58.5% (SE = 1.5) ß blockers, and 67.2% (SE = 1.4) statins. Two of these medications were used by 64.1% (SE = 1.5) of the study population and all 3 by 29.1% (SE = 1.3). In 2011 to 2014, 68.5% (SE = 2.4) of American adults with a history of CAD reported use of aspirin. The use of statins increased from 63.1% in 2005/2006 to 76.8% in 2013/2014. Adults aged 45 to 64 years old, women, and racial/ethnic minorities had lower use of effective cardiac medications compared with older adults, men, and non-Hispanic whites. In conclusion, the use of statins, but not other medications, has increased over the past 10 years among American adults with previously diagnosed CAD. Continued targeted efforts are needed to increase the receipt of effective cardiac medications among all US adults with CAD, especially those aged 45 to 64 years, women, and racial/ethnic minorities.


Assuntos
Síndrome Coronariana Aguda/tratamento farmacológico , Fármacos Cardiovasculares/uso terapêutico , Uso de Medicamentos/estatística & dados numéricos , Etnicidade , Disparidades em Assistência à Saúde/etnologia , Inquéritos Nutricionais/métodos , Grupos Raciais , Síndrome Coronariana Aguda/etnologia , Idoso , Feminino , Humanos , Masculino , Adesão à Medicação/etnologia , Adesão à Medicação/estatística & dados numéricos , Pessoa de Meia-Idade , Prevalência , Sistema de Registros , Estudos Retrospectivos , Estados Unidos/epidemiologia
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