[Radiochemotherapy of inoperable esophageal cancer with 5-FU infusions]. / Radio-Chemotherapie des inoperablen Osophaguskarzinoms mit 5-FU-infusionen.

A combination of radiotherapy and chemotherapy was applied to 13 patients for non-operable oesophageal carcinoma. Included in the twelve-week treatment were radiation doses between 43 and 60 Gy and five FU infusions. Only six patients responded at all to the therapy. Eleven patients died of progressing tumour growth, within two to nine months from diagnosis. One committed suicide with evidence of progressing deterioration. Only one has so far survided without recurrence for 36 months. The study was discontinued for the poor results recorded from those 13 patients. Different cytostatic combinations may, perhaps, yield better results.

[Hormone therapy of metastasizing breast cancer with tamoxifen]. / Die Hormontherapie des metastasierenden Mammakarzinoms mit Tamoxifen.

Out of 79 patients with metastasized carcinoma of the breast in 33% (6 patients) a response to a Tamoxifen therapy could be observed. For complete remissions the remission periods were 12.3 months, for partial remissions 9.9 months and in the group of constant findings 4.9 months. Preferably metastases of the soft parts respond to the therapy. The side effects are very insignificant. The indications for the tamoxifen therapy are represented as well as the importance of the determination of hormone receptors.

[Therapy of bone metastases in breast cancer]. / Die Therapie von Knochenmetastasen beim Mammakarzinom.

This is a retrospective analysis of a series of 124 patients suffering from osseous metastases following surgery of cancer of the female breast and different forms of its treatment. Concerning the rate of survival time the best results could be obtained by chemotherapy (hormones, cytostatic drugs) in combination with irradiation or without it. After chemotherapy the pain relief was prompt and impressive.