Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda.

Contacts of active pulmonary tuberculosis (TB) patients are at risk for Mycobacterium tuberculosis (MTB) infection. Because most infections are controlled, studies during MTB infection provide insight into protective immunity. We compared immune responses of adult household contacts that did and did not convert the tuberculin skin test (TST). Innate and adaptive immune responses were measured by whole blood assay. Responses of TST converters (TSTC) were compared with persistently TST negative contacts (PTST-) and contacts who were TST+ at baseline (TST+). TLR-2, TLR-4, and IFN-γR responses to IFN-γ did not differ between the groups, nor did γδ T cell responses. T cell responses to MTB antigens differed markedly among TSTC, PTST-, and TST+ contacts. Thus, no differences in innate responses were found among the three household contact groups. However, adaptive T cell responses to MTB antigens did differ before and during MTB infection among PTST-, TSTC, and TST+ contacts.

Optically tunable guided-mode resonance filter.

We have demonstrated a guided-mode resonance filter (GMRF) whose properties are tunable with laser illumination through the incorporation of a nonlinear dye. Laser illumination causes a change in the refractive index of the dye-doped portion of the structure, leading to controlled tuning of the GMRF reflectance spectrum. Changes in the refractive index of dye-doped regions are proportional to the intensity of the incident laser beam and are as high as Delta n = 0.09. The reflectance tuning effect occurs on a time scale of many seconds and is completely reversible upon termination of the laser illumination.