Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines.

We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell lines. Here, we further screened these iron compounds, plus four other iron chelates and six iron salts (i.e., 12 oral iron compounds in total), for their effects on biomarkers of cancer and inflammation. Ferric pyrophosphate and ferric EDTA were the main inducers of amphiregulin and its receptor monomer, IGFr1. Moreover, at the maximum iron concentrations investigated (500 µM), the highest levels of amphiregulin were induced by the six iron chelates, while four of these also increased IGfr1. In addition, we observed that ferric pyrophosphate promoted signaling via the JAK/STAT pathway by up-regulating the cytokine receptor subunit IFN-γr1 and IL-6. For pro-inflammatory cyclooxygenase-2 (COX-2), ferric pyrophosphate but not ferric EDTA elevated intracellular levels. This, however, did not drive the other biomarkers based on COX-2 inhibition studies and was probably downstream of IL-6. We conclude that of all oral iron compounds, iron chelates may particularly elevate intracellular amphiregulin. Ferric pyrophosphate additionally induced COX-2, probably because of the high IL-6 induction that was observed with this compound.

Using Hermetia illucens to process Ugandan waragi waste.

Waragi, a form of homemade gin, is produced throughout Uganda in both legal and illegal breweries. Waste produced during the illegal brewing process is predominantly disposed of via indiscriminate dumping into surrounding environments and reports from local communities have indicated this to be harmful to crops and livestock. The larvae of Hermetia illucens are documented to consume a wide range of otherwise unappealing waste products. In addition to this, the prepupal stages of the larvae can serve as a high-quality protein feed for animal livestock. Therefore, the feasibility of the larvae of H. illucens to digest waragi waste was evaluated. A dietary toxicity trial was run to establish an LC50 value for waragi inclusion in larval diets. This was followed by a larger scale trial utilising waragi waste in combination with various in situ available feed stuffs to further assess the viability of processing waragi waste using H. illucens. Larvae were able to eat diets composed of up to 85% waragi waste without any significant impact (p > .01) on survival or growth. When combined with locally available feed sources, e.g. chicken offal, cottonseed cake, sunflower meal or groundnut cake, larvae showed high survival (>95%) and growth rates on diets including 25% waragi waste. Results indicate that H. illucens larvae may be a useful tool in processing waragi waste.

Child maltreatment prevention: a content analysis of European national policies.

Background: Child maltreatment is a major public health concern, which worsens inequalities and perpetuates social injustice through its far-reaching impacts on the health and development of children affected. The aim of this article was to provide a content analysis of the national policies presently used to address child maltreatment and provide an overview of prevention practices being employed in countries of the World Health Organization (WHO) European Region. This analysis will aid in identifying, which policy areas still require further work to prevent child maltreatment. Methods: Three search methods were employed to identify national policies on child maltreatment. A framework based on WHO guidelines for the development of policies was used to conduct a policy analysis of the identified national policies. Results: Two hundred and seventy-eight national policies were identified; of these, 68 met the inclusion criteria for further analysis representing 75% of the WHO Europe Region Member States. Whereas the majority of policies fulfilled most of the WHO criteria for effective policy-making, only 34% had a budget and 6% had quantified objectives. Plans to implement proven child maltreatment prevention interventions were high, with the exception of some countries where the health sector is in the lead. Conclusions: The key policy areas requiring improvement were quantifiable objectives and allocated defined budgets. Hospital-based and home-based child maltreatment interventions were also not widely planned for implementation. Encouraging progress is being made on national policy development to prevent child maltreatment. There are as of yet, several key areas, which warrant increased attention in future policy-making.

Publication patterns in developmental psychology: Trends and social networks.

Interest in publication patterns has been steady. Journals have instituted policies in an effort to curb bias and provide globally representative research. This study aimed to examine if publication patterns were present in two developmental psychology journals. It also explored the social networks of prominent authors and the prevalence of informal author-editor relationships, searching for any potential power groups. Data were taken from empirical articles published between 2005 and 2014 in Child Development (CD) and The International Journal of Early Childhood (IJEC) data points were geographical authorship affiliation, informal author relationships as established by co-publishing, and connections to journal editors via identical affiliation. Results confirmed the previously established North American dominance in published research. In CD a strongly interlinked social network was identified between authors over the 10 years, with 15 chief influentialists binding groups of authors together. Results suggest that patterns are still present in published research in the realm of developmental psychology. To conclude, the potential implications of these patterns within developmental psychology are presented.

Acutifoliside, a novel benzoic acid glycoside from Salix acutifolia.

Ultra high-performance liquid chromatography-mass spectrometry (UHPLC-MS) profiling of a polar solvent extract of juvenile stem tissue of Salix acutifolia Willd. identified a range of phenolic metabolites. Salicortin, 1, a well-known salicinoid, was the major compound present and the study identified young stem tissue of this species as a potential source of this compound for future studies. Three further known metabolites (salicin 2, catechin 3 and tremuloidin 4) were also present. The UHPLC-MS analysis also revealed the presence of a further, less polar, unknown compound, which was isolated via HPLC peak collection. The structure was elucidated by high-resolution mass spectroscopic analysis, 1- and 2-D NMR analysis and chemical derivatisation and was shown to be a novel benzoic acid glycoside 5, which we have named as acutifoliside.

Integration of Nutrition Into Extension and Advisory Services: A Synthesis of Experiences, Lessons, and Recommendations.

BACKGROUND: The need for nutrition-sensitive agriculture is well recognized and of growing interest to global development players. Extension and advisory services (EAS), with their established infrastructure, provide a unique opportunity for nutrition interventions to be implemented at scale with significant reach. OBJECTIVE: To assess current integration of nutrition in EAS, document training provided to EAS agents, and identify challenges and opportunities for the integration of nutrition. METHODS: A mixed methodology was used, which included a systematic literature review covering the following databases: PubMed, ISI Web of Science, Agris, Google Scholar, Econlit, and IBSS. In addition, online surveys and semistructured key informant interviews with stakeholders were performed. Data were collected between December 2012 and June 2013. RESULTS: Based on this study, the most common integration of nutrition into EAS is through efforts to increase the availability of nutritious food. The nutrition training of extension agents is often inadequate, particularly in the realm beyond technical agricultural skill. Additionally, a lack of career opportunities discourages EAS agents form engaging with nutrition integration. The major challenges to integrating nutrition into EAS centered on lack of training for agents, unclear organizational mandates, lack of female inclusion, lack of mobility, and systemic challenges between agriculture and nutrition sectors. Key opportunities for integration efforts are engaging communities, creating a demand for nutrition, and use of innovative communications. CONCLUSIONS: This study demonstrates a large degree of variability across programs in the integration and implementation of nutrition activities into EAS, providing differing opinions on the feasibility of integration. Although the need for nutrition-sensitive agriculture is known, and there is agreement that EAS would provide a positive framework, there are still challenges impeding a simple integration of nutrition into EAS as a delivery platform.