1.
Biull Eksp Biol Med
; 111(6): 603-5, 1991 Jun.
Artigo
em Russo
| MEDLINE
| ID: mdl-1893182
RESUMO
Antioxidants and disulphide bond reducing agents have shown the central N-cholinolytic effect and prevented nicotinic-induced contraction of isolated smooth muscle preparation (ISMP). N-cholinolytic pediphen and antioxidant ionol reduced disulphide bond in the supernatant of mouse brain, but sulphydryl-oxidant agents 5'5-Dithiobis (2-nitrobenzoic acid) abolished N-cholinolytic effect of pediphen on ISMP. It is concluded that reduction of disulphide bond of N-cholinoceptor is a molecular mechanism of its blockade.