RESUMO
Chronic experiments in dogs showed that, after i.v. injection of oxytocin, the latency of activation of gastrointestinal motility by the stimulation of median hypothalamic structures was increased and inhibitory effects of posterior hypothalamic structures on the contractile activity of the digestive tract were intensified. The data obtained suggests that oxytocin facilitates the manifestation of inhibitory effects of the hypothalamus on the motor function of gastrointestinal tract.
Assuntos
Motilidade Gastrointestinal , Hipotálamo/fisiologia , Ocitocina/fisiologia , Animais , Cães , Relação Dose-Resposta a Droga , Estimulação Elétrica , Motilidade Gastrointestinal/efeitos dos fármacos , Hipotálamo/efeitos dos fármacos , Ocitocina/farmacologia , Tempo de Reação/efeitos dos fármacos , Tempo de Reação/fisiologiaRESUMO
Chronic experiments on hypophysectomized dogs with gastric and small intestinal fistulas as well as with hypothalamus-implanted electrodes have shown that blockade of alfa-adrenoreceptors by phentolamine increases the number of the excitatory motility responses while stimulating hypothalamic structures during rest of the gastrointestinal tract and decreases inhibitory effects of the stomach while stimulating hypothalamic structures during work of the digestive tract. The blockade of beta-adrenoreceptors by obsidan induces weakening of excitatory responses of the digestive tract and intensification of inhibitory ones while stimulating hypothalamic structures in hypophysectomized dogs.
Assuntos
Motilidade Gastrointestinal , Hipofisectomia , Hipotálamo/fisiologia , Intestino Delgado/fisiologia , Antro Pilórico/fisiologia , Receptores Adrenérgicos/fisiologia , Animais , Cães , Intestino Delgado/inervação , Vias Neurais/fisiologia , Antro Pilórico/inervaçãoAssuntos
Fenômenos Fisiológicos Cardiovasculares , Fenômenos Fisiológicos do Sistema Digestório , Sistema Hipotálamo-Hipofisário/fisiologia , Animais , Cães , Suco Gástrico/metabolismo , Motilidade Gastrointestinal , Frequência Cardíaca , Hipofisectomia , Corpos Mamilares/fisiologia , Fentolamina/farmacologia , Núcleo Hipotalâmico Ventromedial/fisiologiaRESUMO
In chronic experiments on dogs, preliminary stimulation of corticomedial and parvocellular basal nuclei of amygdala augmented the motor responses of the gastro-intestinal tract to subsequent stimulation of median hypothalamic structures and weakened the inhibitory effects of posterior hypothalamic structures on motility of the digestive tract. After preliminary stimulation of the hypothalamus, the motor responses of stomach and small intestine to subsequent stimulation of corticomedial and parvocellular basal nuclei of amygdala were enhanced. The data obtained suggest existence of a complex functional hypothalamo-amygdaloid interaction, the hypothalamus with its basic mechanisms of regulation of motor function of the digestive tract playing the leading part in this interaction.
Assuntos
Tonsila do Cerebelo/fisiologia , Motilidade Gastrointestinal , Hipotálamo/fisiologia , Intestino Delgado/inervação , Estômago/inervação , Animais , Cães , Estimulação Elétrica , Homeostase , Hipotálamo Posterior/fisiologia , Vias Neurais/fisiologia , Transmissão Sináptica , Núcleo Hipotalâmico Ventromedial/fisiologiaRESUMO
A review of the clinical pattern and heart function in 50 children (aged 6 to 15 years) with mitral valve prolapse (MVP) demonstrated that MVP was mild or of medium severity and had a favourable course in most of the cases. Systolic extratone due to MVP can be manifested to the greatest degree within the low-frequency range of phonocardiograms. Morphometric and functional electrocardiographic parameters were within the normal range in most of the children. The transitory nature of MVP in some of the cases suggests a functional origin of the disease, with vegetovascular dystonia, temporary dysfunction of papillary muscles or reversible myocardial dystrophy as provoking factors.