Role of uterine blood flow disturbances in the development of late gestosis.

OBJECTIVE: Introduction: Chronic endometritis (CE) associated lesions lessen the implantation potential of endometrium and aggravate the course of invasive processes in the uterine vessels The aim: Study of changes in doplerometric parameters of blood flow in spiral and uterine arteries in 17-18 weeks of pregnancy in women with СE in anamnesis. PATIENTS AND METHODS: Materials and methods: Сalculation of systolic/diastolic ratio (SDR), pulse index (PI) and resistive index (RI) has been carried out in 70 pregnant had CE in past history and 10 healthy pregnant women who experienced neither chronic endometritis before pregnancy nor preeclampsia. RESULTS: Results: SDR in SA patients with CE in history and follow-up development of preeclampsia is by 19& higher the control values (р<0,05); PI was 85& higher than the similar one in the control group and RI was 86& higher (р<0,01). In women with a preconception preparation that had a subsequent development of preeclampsia SDR in the spiral artery by 9,7& (p <0,05), PI by 31,7&, and IR by 30,3& (p <0,05) was lower than the corresponding indices in the group of untreated women. CONCLUSION: Conclusions: The findings show the increase in resistance of preplacental bed vessels in women with untreated CE in past history at the aforementioned stage, and the more apparent are the curves of blood flow rate at this stage, the more severe will be the follow-up course of preeclampsia.