RESUMO
OBJECTIVE: We investigated the effects of low-dose leptin treatment on restoration of fertility in young adult male leptin deficient obese mice. EXPERIMENTAL DESIGN AND RESULTS: MMTV-TGF-alpha Lep(ob) Lep(ob) mice (8--10 weeks old) were treated with recombinant mouse leptin. In experiment 1, four mice (5 microg/g body weight leptin followed by 2.5 microg/g) lost weight and impregnated females (number of pregnancies/number of females, 3/6, 5/6, 5/10, 4/10). In experiment 2, Leptin-Obese (2.5 microg/g) and Control-Lean mice weighed significantly less than Control-Obese mice. Epididymal pad weights of Control-Obese mice were the heaviest, followed by those of Leptin-Obese mice, and Control-Lean mice were the lightest. Testes weight was greater in Control-Lean vs Control-Obese mice. Leptin-Obese mice had testes weight not significantly different from either control group. Four of five Leptin-Obese mice impregnated females (4/10, 5/10, 2/10, 5/12, 0/10). CONCLUSIONS: These results indicate that low-dosage mouse recombinant leptin treatment restored fertility to young Lep(ob) Lep(ob) male mice. Although body weights of Leptin-Obese mice were similar to those of lean age-matched mice, epididymal fat pad weights were heavier. International Journal of Obesity (2001) 25, 95-97
Assuntos
Fertilidade/efeitos dos fármacos , Leptina/farmacologia , Obesidade/tratamento farmacológico , Redução de Peso/efeitos dos fármacos , Animais , Feminino , Leptina/administração & dosagem , Leptina/uso terapêutico , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Obesos , Obesidade/fisiopatologia , Tamanho do Órgão , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/farmacologia , Proteínas Recombinantes/uso terapêuticoAssuntos
Alcalose Respiratória/fisiopatologia , Dopamina/farmacologia , Epinefrina/farmacologia , Hemodinâmica/efeitos dos fármacos , Isoproterenol/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Débito Cardíaco/efeitos dos fármacos , Cães , Frequência Cardíaca/efeitos dos fármacos , Concentração de Íons de Hidrogênio , Hipercapnia/fisiopatologia , Resistência Vascular/efeitos dos fármacosRESUMO
A patient with a large mass in his lower trachea presents a real challenge to the anesthesiologist. The anticipated management and alternatives must be discussed with the surgeons beforehand. This report describes a procedure that successfully managed such a case involving a neurofibroma without evidence of neurofibromatosis.