[The application of argon plasma coagulation in thoracic surgery: principles, surgical technique and clinical results]. / Prilozhenie na argon-plazmena koagulatsiia v grudnata khirurgiia--printsipi, operativna tekhnima, klinichni rezultati.

BACKGROUND: In recent years, together with the well-known high-frequency electro-coagulation, the application of plasma coagulation has been also introduced in the clinical practice. The argon plasma coagulator (APC) is one of the representatives of this surgical technique. By its nature, the APC represents a non-contact electrothermal tissue coagulation, combining the principle of the augmented surface and enhanced autogenous haemostatic mechanisms. AIM: The main objective of this study was to evaluate whether APC is an effective and safe modality in the open pulmonary surgery. MATERIALS AND METHODS: For the period from 01.01.2003 to 30.01.2004 year, in the Clinic of Thoracic Surgery, we have applied the technique of APC to 15 patients. The distribution by sex was: 10 males and 5 females. According to the nosological units, the distribution was as follows: pulmonary carcinoma in 3, pulmonary echinococcosis in 4, pleural empyema in 6, pulmonary abscessus in 1 and esophageal ahalasia in 1 patient. In our practice, we have used an argon plasma coagulator of BERCHTOLD GmbH. A power setting of 20W with exposition time 15 s and an argon gas flow setting of 1,5-2 1/h have been used in our series. Energy dose applied in our patients didn't exceed 300 J/cm2. RESULTS: The results we have obtained demonstrate the following fundamental advantages of APC: a possibility to work with long electrode--tissue distance; a possibility for large surface coagulation as well as coagulation under variable angle, limited and well controlled depth of penetration, substantial reduction of carbonization; regular distribution of the energy over the whole coagulating surface, a possibility to treat effectively larger bleeding surfaces. CONCLUSIONS: Although initial, our experience gives us the confidence to recommend the use of APC as an effective and safe procedure in the pulmonary surgery.

[Morphological changes in experimental duodenogastric reflux]. / Morfologicheskie izmeneniia pri duodenogastral'nom reflekse v éksperimente.

The model of a total duodenal-gastric reflux was developed in 20 dogs and morphological changes in the stomach were studied. 5 dogs served as control. Histologic changes occurred 3.5 months and 1 year after the operation were characterized by metachromasia, increased mucus formation, proliferation of epithelial and parietal cells, moderate inflammation. Process of the disease had fluctuations. 6 months after the operation 5 dogs were reoperated for the elimination of reflux and were observed for another 6 months. A complete reversibility of all changes was established. Bacteriological studies showed a considerable increase of bacteria population in the stomach and a pH increase. The authors suggest the term 'reflux gastropathy" to replace the term "alkaline reflux-gastritis".

[Arrest of spermatogenesis by various antibiotics: preliminary experimental results]. / Arrêt de la spermatogénèse par certains antibiotiques: recherches expérimentales préliminaires.

PIP: 9 antibiotics used in urology were injected for 8 days into male rats, and their effects observed on testicular histochemistry and histology. The antibiotics were: spiramycin 25 mg/kg, N-(5-nitro-furfurylidene)-1-amino 2 mg/kg, gentamycin sulfate 1.2 mg/kg, sodium chloramphenicol succinate 30 mg/kg, colimycin methane sulfonate 20,000 U/kg, framycetin sulfate 10 mg/kg, 7-(thiophene-2-acetamido-cephalosporanate sodium 30 mg/kg, crystalline potassium penicillin G 40,000 U/kg and oxytetracycline 10 mg/kg (injection routes not specified). The results were classified into 3 categories: first, gentamycin nitrofurfurlidine-aminohydantoine and oxytetracycline arrested cell division in spermatogonia and partially or totally blocked meiosis in primary spermatocytes. The Feulgen reaction (a stain for DNA) was faint in the germinal epithelium. In the second category were spiramycin, thiophene-acetamido-cephalosporanate, colimycin and framycetin, which inhibited mitosis in spermatogonia, therefore permitting few primary spermatocytes to reach metaphase. In the third group were penicillin G and chloramphenicol which partly or completely blocked mitotsis in spermatogonia. In all cases interstitial capillaries were congested. The severity of effect was least with penic illin, moderate with oxytetracycline, and generalized and severe with the others. Histochemical stains showed strong activity of glucose-6-phosphate and isocitric dehydrogenase in the interstitial cells, and in the spermatogonia, but lower than normal in the spermatids and spermatozoa. Glutamate dehydrogenase was low in spermatogonia and primary spermatocytes. Classification of these antibiotics according to these results did not resemble any known chemical or antibacterial class ification.^ieng