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Antibiot Khimioter ; 35(5): 13-6, 1990 May.
Artigo em Russo | MEDLINE | ID: mdl-2116780

RESUMO

A mutant strain of the bruneomycin-producing culture which produced up to 10% of the minor component was selected. The component was identified as streptonigrone. It was isolated and its physicochemical properties and antibacterial activity were investigated. Trimethylsilyl derivatives of streptonigrone and bruneomycin were prepared. Their PMR spectra and electron impulse mass spectra were studied. Streptonigrone was shown to have antibacterial and cytotoxic activities which was 1 to 2 orders of magnitude lower than that of bruneomycin.


Assuntos
Estreptonigrina/análise , Bacillus/efeitos dos fármacos , Bacillus subtilis/efeitos dos fármacos , Escherichia coli/efeitos dos fármacos , Modelos Químicos , Saccharomyces cerevisiae/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Estreptonigrina/farmacologia
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