[Preparation of the adrenal gland for autografting in Itsenko-Cushing's disease]. / Podgotovka nadpochechnika dlia autotransplantatsii pri bolezni Itsenko--Kushinga.

The paper is devoted to surgical treatment of patients with Itsenko-Cushing disease. Altogether 16 patients after adrenalectomy with subsequent autotransplantation of the gland on a vascular pedicle were investigated. The purpose was to study a morphological picture of the gland in ischemia and the determination of time required for blood flow recovery in the gland. Light and electron microscopy, radiological and clinical methods were employed. Emerging of the removed gland before autotransplantation into a nutrient medium for 30 min. (before blood flow recovery in a graft) was shown to damage neither secretory cells nor the components of the microcirculatory bed. The extracorporal condition of the gland for 1 h was accompanied by an increase in autolytic processes, especially in the medullary substance and deep layers of reticulated cortical zone, but most of the adrenocorticocytes preserved their viability and structural features of steroid activity, which became an indication for effective autotransplantation of the adrenal gland on a vascular pedicle in the treatment of Itsenko-Cushing disease.

[Hypophyseal and adrenal hormones and the immune reactivity of patients with Itsenko-Cushing disease after an adrenal autograft]. / Gormony gipofiza i nadpochechnikov, immunnaia reaktivnost' u bol'nykh bolezn'iu Itsenko--Kushinga posle autotransplantatsii nadpochechnika.

The authors employed for the first time the method of heterotopic autotransplantation of the adrenals on a vascular pedicle in patients with Itsenko-Cushing disease. It was established that heterotopic transplantation of the adrenals results early in a significant reduction of the level of cortical hormones and insignificant change as compared with initial state of the immune status. All terms were characterized by humoral and cellular immune deficit. Results indicate the expediency of using this method. Adrenal transplantation prevents the development of hypocorticism.