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Autoimmun Rev ; 13(4-5): 569-73, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24424170

RESUMO

Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.


Assuntos
Anemia Aplástica/diagnóstico , Anemia Aplástica/tratamento farmacológico , Anemia Aplástica/epidemiologia , Anemia Aplástica/metabolismo , Animais , Autoanticorpos/imunologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Imunossupressores/uso terapêutico , Linfócitos T/imunologia , Telômero/genética
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