1.
Org Lett
; 19(23): 6304-6307, 2017 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29135261
RESUMO
2-Hydroxymethylpyridines undergo nickel-catalyzed hydrogenolysis upon activation with a chlorophosphate. Reactions employ diethylzinc and are proposed to proceed through secondary benzylzinc reagents. Quenching with deuteromethanol provides straightforward incorporation of a deuterium label in the benzylic position. Intramolecular conjugate additions with α,ß-unsaturated esters are also demonstrated and support the intermediacy of a benzylzinc complex.