Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

OBJECTIVE: To document long-term results associated with an coordinated plan of care for acutely burned hands in children. SUMMARY AND BACKGROUND DATA: Optimal hand function is a crucial component of a high-quality survival after burn injury. This can be achieved only with a coordinated approach to the injuries. Long-term outcomes associated with such a plan of care have not been previously reported. METHODS: Over a 10-year period, 495 children with 698 acutely burned hands were managed at a regional pediatric burn facility; 219 children with 395 injured hands were followed in the authors' outpatient clinic for at least 1 year and an average of >5 years. The authors' approach to the acutely burned hand emphasizes ranging and splinting throughout the hospital stay, prompt sheet autograft wound closure as soon as practical, and the selective use of axial pin fixation and flaps. Long-term follow-up, hand therapy, and reconstructive surgery are emphasized. RESULTS: Normal functional results were seen in 97% of second-degree and 85% of third-degree injuries; in children with burns involving underlying tendon and bone, 70% could perform activities of daily living and 20% had normal function. Reconstructive hand surgery was required in 4.4% of second-degree burns, 32% of third-degree burns, and 65% of those with injuries involving underlying bone and tendon. CONCLUSIONS: When managed in a coordinated long-term program, the large majority of children with serious hand burns can be expected to have excellent functional results.

Management of massive calvarial exposure in young children.

Although small areas of exposed calvaria commonly occur in seriously burned children, these wounds are generally straightforward management problems. In contrast, management of the nearly completely exposed calvaria is an extraordinarily difficult problem--but is fortunately rare. Over the past 15 years, we have treated 119 children with full-thickness calvarial wounds requiring grafting. Four (3.4%) of these patients (average age, 2.9 years; range, 22 months to 5.5 years) had massive exposure of nonviable calvaria, defined as 75% or more of the surface area of the calvaria. These wounds were open an average of 28 months (range, 6 to 45 months). We have concluded that optimal management involves staged debridement of the desiccated outer table with a high-speed drill, taking appropriate precautions to avoid air embolism or inadvertent dural injury in the area of sutures or fontanelles. The resulting wounds quickly granulate and can be autografted.

Reconstruction of electrical burns of the oral commissure with a ventral tongue flap.

Reconstruction of the oral commissure following electrical burn injury is a challenging problem. The commissure is a thin, delicate structure that is highly mobile and essential to normal facial appearance and expression. When there is full-thickness destruction of vermilion, mucosa, skin, and orbicularis muscle, the resulting contracture alters adjacent structures, displaces the commissure, and distorts facial animation. Utilizing a composite ventral tongue flap of mucosa and muscle in the reconstruction of the commissure permits effective release of scar contracture and replaces destroyed mucosa and muscle bulk. Remaining structures can be returned to their normal location, and the three-dimensional contours of the oral commissure can be better restored. The use of this flap in 21 patients has resulted in improved mobility, more normal facial expression, and more consistent results in the reconstruction of a wide range of commissure deformities.

Comparison of the effects of interleukin-1 beta on proteoglycan synthesis by human skin and post-burn normal scar explant cultures.

The effect of interleukin (IL)-1 beta on proteoglycan (PG) synthesis and secretion, into culture medium by normal human skin and post-burn human normal scar using tissue explants in culture, was investigated. Following exposure of different tissues to labeling with Na2[35SO4] in the presence and absence of IL-1 beta, the extractable [35SO4]PG (isolated from 0.15 M NaCl and 4 M Gdm. Cl extracts), non-extractable [35SO4]PG (isolated after papain treatment of residual tissue), and [35SO4]PG secreted into culture medium were analyzed for contents and distribution. The contents of [35SO4]PG as measured by [35SO4] incorporation indicate differences in [35SO4]PG production of extractable and non-extractable PGs and also in the PGs released into the culture medium. Examination of the sizes of [35SO4]PGs on Sepharose CL-6 beta columns with and without treatment of IL-1 beta shows that the size of non-extractable [35SO4]PG decreases after IL-1 beta treatment. Cellulose acetate plate electrophoresis of these [35SO4]PG fractions shows that the distribution of PGs alters after treatment with IL-1 beta. These results indicate that burn wound healing abnormalities (scarring) is related to a change in the level of PGs, and may be modified by IL-1 beta treatment.

Large-volume suction lipectomy: an analysis of 108 patients.

Suction lipectomy was initially advocated for the treatment of localized collections of fat and for the removal of less than 1500 ml of material. However, many patients wished to have multiple areas treated or had diffuse collections of fat. In such instances, the removal of over 1500 ml of material and circumferential lipectomy are necessary to provide optimal aesthetic results. However, when over 1500 ml of material is removed, anesthetic requirements, fluid replacement, and treatment of blood loss become important if the operation is to be performed safely. We have treated 108 patients who had over 1500 ml of material removed. Eight-eight percent of the patients were female; 12 percent were male. Using the body-mass index, 3 percent of patients were underweight, 70 percent were normal weight, and 27 percent were overweight. Fifty-five patients (51 percent) had 1500 to 2499 ml of material removed, 26 patients (24 percent) had 2500 to 3499 ml removed, 16 patients (15 percent) had 3500 to 4499 ml removed, and 11 patients (10 percent) had over 4500 ml removed. All patients were treated in the hospital; 44 percent were admitted after surgery. A total of 227 units of autologous and 2 units of homologous blood were transfused. As measured by a computerized monitor, the average amount of blood in the material removed from thighs was 30 percent; from abdomens, the blood loss was 45 percent. The aesthetic results were generally excellent. No complications were encountered. A few patients developed undesired sequelae, the most common of which was seroma formation, which occurred in 19 percent of those who had suction of abdominal-wall fat. We believe that large-volume suction lipectomy is safe and efficacious, provided attention is directed to such important aspects of patient care as anesthesia, fluid replacement, and blood loss.

Proteoglycan synthesis in human skin and burn scar explant cultures.

The synthesis of proteoglycans (PG) by normal human skin, and normal and hypertrophic scars were compared using tissue explants in culture. Newly synthesized PG were labelled with [35S]Na2SO4. Significant differences were found in the proportion of [35S]-radio-labelled incorporation of PG in the tissue and accumulation of [35S]PG in culture medium in the different tissues. The rate of PG biosynthesis in all three tissue types occurred in two phases. There was an initial phase of PG synthesis occurring at 0-3 h and a later phase that occurred at 3-18 h [35S]-labelled PG were isolated and characterized by Sepharose CL-6B chromatography and cellulose acetate electrophoresis. The results showed that the hypertrophic scar tissue and its culture medium contained higher proportions of dermatan sulphate (DS), chondroitin sulphate (CS) and DS' PG than the normal skin fractions. These results suggest that abnormal scarring is related to a change in the level of PG synthesis during the burn injury repair process.

Conchal transposition flap for postburn ear deformities.

Severe thermal injuries to the external ear often lead to extensive loss of peripheral structures such as helix and lobule but frequently spare the more central parts of the ear, even though they may be grossly deformed by scar contracture. The use of spared conchal structures as a transposition flap in combination with remodeling of the residual auricle and release of surrounding scar when indicated has been a useful technique in the reconstruction of a frequently occurring type of postburn ear deformity. Twenty-four ears have been reconstructed in 18 patients over the past 5 years using a conchal transposition flap. The residual concha with its overlying skin can be transposed superiorly, based on a very narrow pedicle in the area of the crus helicis. The raw central area remaining is then resurfaced with a split-thickness skin graft. This technique maximally utilizes the unique remaining auricular elements and can provide a satisfactory reconstruction in selected patients without resorting to more complex and extensive procedures. There have been no significant complications in this series, and patient acceptance of the results has been excellent.

Skin sensation after suction lipectomy: a prospective study of 50 consecutive patients.

Using a reproducible pain stimulus, skin sensation was evaluated in a prospective study of 50 consecutive patients who underwent suction lipectomy. A total of 294 anatomic areas were evaluated and treated. Before operation, many patients were found to have patchy areas of decreased sensation, a condition that was unknown to them. Initially after surgery, all patients had decreased sensation in the treated areas. However, sensation usually returned to normal in 6 to 8 months. In some patients, sensory return to preoperative levels took as long as 1 year, and in a few, patchy areas of decreased sensation were present even longer. In general, the larger the treated area, the larger are the area and degree of sensory loss and the slower is the return of sensation.

Thumb reconstruction in the burned hand by advancement pollicization of the second ray remnant.

Reconstruction of 15 thumbs in 14 patients with severe postburn deformity has been carried out by advancement and transferral of the second ray remnant onto the remaining proximal thumb metacarpal stump. This technique combines the advantages of thumb lengthening and pollicization procedures in a single operation and has been a useful method for restoration of single hand prehension in the severely burned mitten hand.

Preoperative magnification angiography of donor and recipient sites for clinical free transfer of flaps or digits.

Based on the 14 free flap transfers we present with full survival, we recommend peroperative magnification angiography of both the recipient and donor sites. In our hands, this type of preoperative assessment seems to increase the margin of safety.