1.
J Asian Nat Prod Res
; 26(7): 833-842, 2024 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38584456
RESUMO
Fourteen diphyllin 4-C-substituted alkylide derivatives were designed and synthesized using a Heck coupling and subsequent hydrogenation reaction. Olefins 3g and 3i exhibited the highest cytotoxicity on breast cancer cell lines MCF-7 with IC50 values of 0.08 and 0.07 µM, and they showed weaker V-ATPase inhibitory potency compared to diphyllin.