1.
J Org Chem
; 84(16): 9937-9945, 2019 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31347848
RESUMO
Novel copper/B2pin2-catalyzed difluoroalkylation of methylenecyclopropanes with bromodifluorinated acetates and acetamides via a tandem radical process involving ring-opening/intramolecular cyclization has been reported. This protocol is not only tolerated to a diverse range of substrates but also applicable to the synthesis of useful difluoromethylated compounds. Moreover, the reaction could be performed on a gram scale with a high yield, which opens up the possibility for practical applications.