[Clinical and pathologic characteristics of bladder squamous carcinoma].

From 1973 to 1991, 782 patients with bladder tumor were admitted to this hospital. 23 (2.9%) of them were pathologically confirmed as squamous carcinoma. Clinically, 20 patients showed hematuria, 3 irritation signs of bladder, and 13 both signs. In this group, 82% the tumors belonged to B to D stage and 61% were of grade II. Six of 17 patients showed diffused eosinophil cell infiltration, suggesting a close relationship between bladder squamous carcinoma and inflammation. Bladder polycentric biopsy and exfoliative cytologic urocrisia were emphasized in preoperative diagnosis.

Distribution of juxtaglomerular cells and synthesis and release of renin granules in patients with renal artery stenosis.

100 pieces of renal tissue from 4 patients with renal artery stenosis were studied histologically. Juxtaglomerular cells were found not only in the region close to the glomerulus but also in the proximal 2/3 of the afferent arteriole of the glomerulus, but not in the interlobular arterioles. In the cytoplasm of juxtaglomerular cells, three kinds of granules were found: crystalline granules (immature), the round or ovoid granules (mature), and the lobulated granules (fusion). Renin was synthesized in the rough endoplasmic reticulum and packaged in the Golgi complex. Electron microscopic findings suggested that the secretory microvesicles were produced on the surface of Golgi complex. They fused to form primary crystalline granules, which were enlarged by renin supplied by transportation vesicles and finally formed typical crystalline granules. The mature renin granules (round or ovoid) moved toward the periphery of the cytoplasma. Their limiting membranes on the side toward the basement membrane disintegrated and formed microvesicular bodies passing through the periplasm, and the basement membrane and were discharged into the interstitial matrix.