Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment.

Osteomyelitis, caused by purulent bacteria invading bone tissue, often occurs in long bones and seriously affects the physical and mental health and working ability of patients; it can even endanger life. However, due to bone cavity structure, osteomyelitis tends to occur inside the bone and thus lacks an effective treatment; anti-inflammatory treatment and repair of bone defects are necessary. Here, we developed injectable hydrogel microspheres loaded with naringin and bone marrow mesenchymal stem cells, which have anti-inflammatory and osteogenic properties. These homogeneous microspheres, ranging from 200 to 1000µm, can be rapidly fabricated using an electro-assisted bio-fabrication method. Interestingly, it was found that microspheres with relatively small diameters (200µm) were more conducive to the initial cell attachment, growth, spread, and later osteogenic differentiation. The developed microspheres can effectively treat tibial osteomyelitis in rats within six weeks, proving their prospects for clinical application.

The impacts of environmental governance on political turnover of municipal party secretary in China.

Political incentive is one of the most efficient methods to promote local officials to push for both economic growth and environmental progress in the context of China. Since previous scholars have never investigated the relationships between political turnover and environmental governance at the municipal level, in this work, we proxy pollution by SO2, COD, SOOT, and NHx and examine whether environmental performance affects the political turnover of the municipal party secretary by exploiting a panel conditional logit with a fixed-effect model for the period 2002-2013. The results indicate that environmental performance does not significantly impact the turnover of municipal party secretaries, offering evidence that an increase of SO2 is associated with the likelihood of promotion under the panel multinomial logit approach. However, a higher GDP growth rate plays the determinant factor affecting the promotion of China's municipal party secretaries. Specific policy recommendations are proposed in accordance with our empirical findings.