RESUMO
Few studies have examined the genes related to risk fac-tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rup-ture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups. SNP genotypes and allele frequencies were analyzed by the chi-square test. Logistic regression analysis identified hypertension as a factor that increased IA risk (P = 1.0 x 10(-4); OR, 2.500; 95%CI, 1.573-3.972); IA was associated with two SNPs in the TSLC2A9 gene: rs7660895 (P = 0.007; OR, 1.541; 95%CI, 1.126-2.110); and in the TOX gene: rs11777927 (P = 0.013; OR, 1.511; 95%CI, 1.088-2.098). Subsequent removal of the influence of family relationship identified between 12 of 119 patients enhanced the significant association of these SNPs with IA (P = 0.001; OR, 1.691; 95%CI, 1.226-2.332; and P = 0.006; OR, 1.587; 95%CI, 1.137-2.213 for rs7660895 and rs11777927, respectively). Fur-thermore, the minor allele of rs7660895 (A) was also associated with IA rupture (P = 0.007; OR, 2.196; 95%CI, 1.230-3.921). Therefore, hypertension is an independent risk factor for IA. Importantly, the TSL-C2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of IAs, and rs7660895 may be associated with IA rupture.
Assuntos
Aneurisma Roto/genética , Proteínas Facilitadoras de Transporte de Glucose/genética , Proteínas de Grupo de Alta Mobilidade/genética , Hipertensão/genética , Aneurisma Intracraniano/genética , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Alelos , Aneurisma Roto/etnologia , Aneurisma Roto/patologia , Povo Asiático , Estudos de Casos e Controles , Feminino , Expressão Gênica , Frequência do Gene , Loci Gênicos , Proteínas Facilitadoras de Transporte de Glucose/metabolismo , Proteínas de Grupo de Alta Mobilidade/metabolismo , Humanos , Hipertensão/etnologia , Hipertensão/patologia , Aneurisma Intracraniano/etnologia , Aneurisma Intracraniano/patologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
The lateral shifts from a slab of lossy chiral metamaterial are predicted for both perpendicular and parallel components of the reflected field, when the transverse electric (TE)-polarized incident wave is applied. By introducing different chirality parameter, the lateral shifts can be large positive or negative near the pseudo-Brewster angle. It is found that the lateral shifts from the negative chiral slab are affected by the angle of incidence and the chirality parameter. In the presence of inevitable loss of the chiral slab, the enhanced lateral shifts will be decreased, and the pseudo-Brewster angle will disappear correspondingly. For the negative chiral slab with loss which is invisible for the right circularly polarized (RCP) wave, we find that the loss of the chiral slab will lead to the fluctuation of the lateral shift with respect to the thickness of the chiral slab.The validity of the stationary-phase analysis is demonstrated by numerical simulations of a Gaussian-shaped beam.
