1.
Acta Pol Pharm
; 69(4): 623-8, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22876604
RESUMO
A series of ampicillin and amoxicillin derivatives were prepared by N-acylation with N1-substituted 1, 2-dihydro-2-oxoquinoline carboxylic acids by Schotten-Baumann procedure and evaluated as inhibitors of Pseudomonas aeruginosa using molecular docking study. Most of the derivatives showed remarkableactivity against Gram positive and Gram negative bacteria in vitro.