Agenesis of the corpus callosum: symptoms consistent with developmental disability in two siblings.

Agenesis of the corpus callosum (AgCC) is a congenital disorder that disrupts the development of neurological structures connecting the right and left hemispheres of the brain. In addition to neurological symptoms, many individuals with AgCC demonstrate marked deficits in social, communication, and adaptive skills. This paper presents two case studies of congenital AgCC in siblings with socioemotional and behavioral symptoms consistent with developmental disability, but with notably different symptom presentations and clinical needs. Conclusions from these cases suggest that unique symptom profiles of individuals with AgCC warrant careful consideration for referral to appropriate academic and habilitative services.

Neuropsychological assessment in prisons: ethical and practical challenges.

Cognitive deficits, substance abuse, and mental illness are common among prisoners. Thus, for many prisoners, neuropsychological evaluations may be indicated to assess the degree of impairment and how these impairments may affect their behavior in the prison environment. However, many neuropsychological tests were not designed for or normed on prisoners. This article highlights the unique ethical and practical challenges to providing neuropsychological services to incarcerated individuals. Specifically, it discusses (a) limits to confidentiality, (b) issues related to informed consent, (c) how prison conditions may compromise the validity of testing, and (d) the impact of third-party observation of the evaluation. Recommendations and suggestions for resolving some of these difficulties are offered.

NEUROPSYCHOLOGICAL FUNCTIONING IN PRISONERS WITH AND WITHOUT SELF-INJURIOUS BEHAVIORS: Implications for the Criminal Justice System.

Neuropsychological functioning has not yet been investigated among prisoners who engage in self-injurious behaviors, specifically attempted suicide and nonsuicidal self-injury (NSSI). The purpose of this study was to investigate neuropsychological functioning in prisoners with and without histories of NSSI and attempted suicide. The sample consisted of 173 male prisoners referred for neuropsychological evaluation. Of participants, 56% reported a history of self-injury. Performance on the neuropsychological domains of intelligence, memory, attention, motor functioning, and executive functioning was assessed. No group differences were found among those with NSSI, with NSSI and suicide attempts, and with no history of deliberate self-harm, although functioning was poor in all domains. Implications of the high prevalence of self-injury in this prison sample, as well as implications of impaired functioning on the treatment of self-injurious behaviors, are discussed.

Extending the administration time of the letter fluency test increases sensitivity to cognitive status in aging.

The authors examined whether extending the administration time of letter fluency from 1 minute per letter trial (standard administration) to 2 minutes increased the sensitivity of this test to cognitive status in aging. Participants (mean age = 84.6) were assigned to cognitive impairment (n = 20) and control (n = 40) groups. Pearson correlations and scatter plot analyses showed that associations between the Dementia Rating Scale scores and letter fluency were higher and less variable when performance on the latter was extended to 2 minutes. Analysis of variance (ANOVA) showed that the cognitive impairment group generated fewer words in the second minute of the letter fluency task compared to the control group. Finally, discriminant function analyses revealed that extending the letter fluency trials to 2 minutes increased discrimination between the control and cognitive impairment groups.

Evaluation of a neuropsychological screen in an incarcerated population.

The Brief Neuropsychological Cognitive Examination (BNCE) is a screening device designed to rapidly assess neuropsychological functioning. The availability of an effective and efficient screen for neuropsychological and/or cognitive disorders is an important concern within various settings such as correctional facilities, where there are likely to be large numbers of individuals in need of evaluation. In the current study the utility of the BNCE in detecting cognitive impairments among a clinical sample of incarcerated individuals was evaluated by comparing performance on this instrument to performance on measures of general cognitive functioning. Results indicate that the BNCE demonstrates some utility in its ability to determine those in need of further evaluation of cognitive functioning.

Questioning the rule of thumb: can verbal tasks be administered during the CVLT-II delay interval?

In the manual for the California Verbal Learning Test - II (CVLT-II), the authors suggest that nonverbal, rather than verbal, tasks be administered during the delay interval between administrations of the Short- and Long-Delay Recall trials of this test. They contend that this method minimizes the retroactive interference produced by intervening tasks. The purpose of the current study was to compare the extent to which verbal and nonverbal intervening tasks produce retroactive interference on CVLT-II List A recall following the long-delay. Participants in the present study were 120 undergraduate students. All participants completed the CVLT-II, and were randomly assigned to a group in which they were administered either a verbal (WAIS-III Vocabulary or Peabody Picture Vocabulary Test - IIIB) or nonverbal (Raven's Standard Progressive Matrices or WAIS-III Block Design) intervening task during the long-delay interval of the CVLT-II. Statistical analyses revealed that regardless of the type of intervening task given, participants in all groups recalled the same number of words and produced a similar number of intrusions during the CVLT-II recall trials. This indicates that not all verbal tasks produce retroactive effects beyond those produced by nonverbal tasks.

Multidimensional assessment of impulsivity in undergraduate hazardous drinkers and controls.

OBJECTIVE: Alcohol misuse in college students represents a significant public health problem. Toward improving the understanding of determinants of collegiate alcohol misuse, the current study examined several dimensions of impulsivity in relation to hazardous drinking in college students. METHOD: A one-way, two-group, cross-sectional design was used to compare hazardous drinkers (HZD) with social drinkers (SOC). HZD drinkers were required to score 6 or more on the Alcohol Use Disorders Identification Test (AUDIT); SOC drinkers were required to score 1-5 on the AUDIT. The sample comprised 93 participants (56% HZD; 76% male) who were recruited from a medium-sized public university. Participants were assessed under neutral conditions using the Eysenck Impulsivity Questionnaire (EIQ), Delay Discounting Task (DDT), and Stanford Time Perspective Inventory (STPI). RESULTS: Consistent with predictions, HZD participants exhibited significantly greater impulsivity on the EIQ-Impulsivity subscale (p < .001), the STPI-Present Hedonism subscale (p < .01), and the STPIFuture subscale (p < .01); however, no differences were evident on the DDT (p > .40). The HZD group also scored marginally higher than the SOC group on the EIQ-Venturesomeness subscale (p < .10). CONCLUSIONS: These findings suggest that greater impulsivity is associated with alcohol misuse in college students, most prominently in the area of propensity toward risk-taking and nonplanning (EIQ-Impulsivity subscale). The correspondence between these findings and previous studies, methodological considerations, and the need for prospective studies on impulsivity and alcohol misuse in college students are discussed.

Vocabulary and verbal fluency of bilingual and monolingual college students.

We assessed the English vocabulary and verbal fluency of college students who were either bilinguals who were born abroad and spoke English or monolingual speakers of English. We examined the relationship between age of arrival to the U.S. of bilinguals and their English vocabulary. The bilinguals' performance on English vocabulary was in the average range. However, despite arriving to the U.S. at a relatively young age, and having sufficient command of English to attend a competitive university, the bilinguals had lower receptive and expressive English vocabularies than their monolingual peers. Age of arrival was moderately correlated with English vocabulary scores. The younger the bilingual students were when they arrived to the U.S., the better their English vocabulary. Both groups had similar performance on phonetic fluency. However, the bilingual group performed significantly lower in semantic fluency. This pattern of performance in verbal fluency is consistent with that found in previous studies.

Divergent validity of measures of cognitive distortions, impulsivity, and time perspective in pathological gambling.

The present study assessed the divergent validity of several self-report and objective behavioral measures for assessing pathological gambling using three samples divided by South Oaks Gambling Scale score [Lesieur, & Blume (1987). American Journal of Psychiatry, 144, 1184-1188]: pathological gamblers, potential pathological gamblers, and non-pathological gamblers. Self-report measures included the Gamblers' Beliefs Questionnaire [GBQ; Steenbergh, Meyers, May, & Whelan (2002). Psychology of Addictive Behaviors, 16, 143-149], the Gambling Passion Scale [GPS; Rousseau, Vallerand, Ratelle, Mageau, & Provencher, (2002). Journal of Gambling Studies, 18, 45-66], the Eysenck Impulsivity Questionnaire [EIQ; Eysenck, & Eysenck (1978). Psychological Reports, 43, 1247-1255], and the Stanford Time Perspective Inventory [STPI; Zimbardo, & Boyd (1999). Journal of Personality and Social Psychology, 77, 1271-1288]. Behavioral tasks included the delay discounting task [Madden, Petry, Badger, & Bickel (1997). Experimental & Clinical Psychopharmacology, 5, 256-263] and the Future Time Perspectives [FTP; Wallace (1956). Journal of Abnormal Psychology, 52, 240-245]. The GBQ, GPS, Impulsivity subscale of the EIQ, and DDT all exhibited robust divergent validity, however, neither measure of time perspective discriminated between groups. Applications of these findings to etiological research and clinical contexts are discussed.

Convergent validity of measures of cognitive distortions, impulsivity, and time perspective with pathological gambling.

The present study investigated the convergent validity of the Gamblers' Beliefs Questionnaire (GBQ), Gambling Passion Scale (GPS), Eysenck Impulsivity Questionnaire (EIQ), and Stanford Time Perception Inventory (STPI) in reference to pathological gambling. The authors recruited 105 undergraduates representing categories of pathological gamblers, potential pathological gamblers, and nonpathological gamblers and administered the measures under neutral conditions. Both subscales of the GBQ and GPS and the Impulsivity subscale of the EIQ exhibited strong convergent validity, whereas the STPI showed weaker correspondence with symptoms of pathological gambling. Applications and limitations of these findings are discussed.

The function of self-harm behavior in a forensic population.

This article examines the functions of self-injurious behavior (SIB) in forensic populations. The cases of four individual offenders who have engaged in SIB are presented. These cases depict the four main functions of self-harm behaviors including (a) suicidal intent, (b) manipulation of the environment, (c) emotion regulation, and (d) a response to psychotic delusions or hallucinations. Assessment and treatment implications are discussed.

Temporal effects of dialysis on cognitive functioning in patients with ESRD.

BACKGROUND: Although dialysis has been shown to improve cognitive deficits resulting from uremia, little is known about potential temporal variations in cognitive measures between hemodialysis treatments. METHODS: We studied dialysis patients for possible fluctuations in attention and memory by using repeatable neuropsychological measures. Twenty patients undergoing hemodialysis on a thrice-weekly dialysis schedule were assessed at intervals of 1, 24, and 67 hours after the last weekly hemodialysis session. For purposes of comparison, we also studied 10 patients on continuous ambulatory peritoneal dialysis (CAPD) therapy at similar intervals. RESULTS: CAPD patients showed overall stable performance on measures of attention and memory. However, hemodialysis patients showed significant changes (P < 0.05) in auditory memory for both immediate and delayed recall, with the greatest impairment occurring 67 hours postdialysis. Hemodialysis patients also showed a significant change (P < 0.05) in attention between the second and third test periods, ie, 24 to 67 hours postdialysis, with the greatest impairment seen at the 67-hour assessment time. No relationship was found between performance on measures of cognition and levels of postdialysis fatigue in hemodialysis patients. CONCLUSION: CAPD patients showed cognitive stability, whereas hemodialysis patients showed temporal fluctuations in cognitive performance.

The sensitivity of dual-task performance to cognitive status in aging.

The present study examined dual-task performance in elders with cognitive impairments and normal controls. The participants (N = 60; M age = 84.6) were recruited from residential facilities and the community. They were assigned to one of three groups: (1) cognitive impairment; (2) residential facility control; (3) community control. Two different dual-task conditions were comprised of simple tests that are presumably processed via separate perceptual modalities: 1 visual-manual and 1 auditory-verbal. The first condition consisted of a visual cancellation test and an auditory digit span. The second condition was comprised of an alternate form of the visual cancellation test and letter fluency. MANOVA examined the effect of cognitive status (3-level independent variable) on 3 indices of dual-task performance (letter fluency, digit span, visual cancellation). Analyses controlled for age, education and performance on each test when performed alone. The results revealed that the cognitive impairment group incurred significantly greater dual-task costs compared to both control groups. Furthermore, as was evident from discriminant function analyses, the dual-task measures were very accurate and better than the traditional neuropsychological measures at discriminating elders with cognitive impairments from normal controls. (JINS, 2004, 10, 230-238.)

Comparison of the predictive power of socio-economic variables, severity of injury and age on long-term outcome of traumatic brain injury: sample-specific variables versus factors as predictors.

The primary objective of this study was to measure the predictive power of pre-injury socio-economic status (SES), severity of injury and age variables on the very long-term outcomes of traumatic brain injury (TBI). By applying a within-subjects retroactive follow-up design and a factor analysis, the study also compared the relative power of sample-specific predictors to that of more commonly used variables and conceptually based factors. Seventy-six participants with severe TBI were evaluated at an average of 14 years post-injury with an extensive neuropsychological battery. The results show that pre-injury SES variables predict long-term cognitive, psychiatric, vocational, and social/familial functioning. Measures of severity of injury predict daily functioning, while age at injury fails to predict any of these variables. Sample-specific predictors were more powerful than more commonly used predictors. Implications regarding long-term clinically based and conceptually based prediction, and those regarding comparisons of predictors across samples are further discussed.