1.
Bioorg Med Chem Lett
; 19(2): 528-32, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19081251
RESUMO
The optimisation of a tertiary sulfonamide high-throughput screening hit is described. A combination of high-throughput chemistry, pharmacophore analysis and in silico PK profiling resulted in the discovery of potent sulfonamide oxytocin receptor antagonists with oral exposure and good selectivity over vasopressin receptors.