[Treatment of chronic rhinitis in children]. / Lechenie khronicheskogo nasmorka u detei.

This paper discusses involvement of intestinal dysbacteriosis in nasal inflammation. Altogether 42 children of preschool age with chronic rhinitis were examined. It was found that microbial changes in the nasal cavity were related to the degree of intestinal dysbacteriosis, which was detected in most patients. The drugs that were used in combined therapy to treat microbial changes in the nasal mucosa and intestine produced good clinical and bacteriological effects. The 4 month follow-up showed that the children on the combined therapeutic protocol remained in the remission stage throughout this time period, whereas 85 +/- 10% of the control children exhibited exacerbation of the inflammatory process in the nasal cavity within 2-3 weeks after onset of standard treatment.

[Lysozyme in the combined therapy of erythematosis]. / Lizotsim v kompleksnoi terapii éritematoza.

Lysozyme was administered to 57 patients with lupus erythematosus (LE) for 10 days according to 4 schemes: Group 1 (n = 10)--30 mg of lysozyme 3 times a day sublingually; Group 2 (n = 10)--100 mg daily i.m.; Group 3 (n = 10)--100 mg twice a day i.m.; Group 4 (n = 27)--100 mg 3 times a day i.m. After a course of lysozyme therapy patients with discoid and disseminated LE were prescribed delagil, those with systemic LE were administered corticosteroid hormones in moderate doses or presocyl. The treatment was well tolerated, only 2 (3.5%) patients developed toxicoderma. The results evidence that lysozyme efficacy is not inferior to that of levamisole but this agent is better tolerated. Clinical and paraclinical efficacy was higher in Groups 1 and 4; cellular, humoral, and local immunity parameters, as well as the characteristics reflecting the inflammatory processes evidence positive changes developing as a result of lysozyme therapy, these changes persisting in the majority of cases during further combined treatment. Therapy with low doses of lysozyme is indicated for patients with the immune status disorders mainly. If changes in the nonspecific resistance predominate, the scheme used in Group 4 is advisable.

[Microbial ecology of the intestines in health and in pathology]. / Mikrobnaia ékologiia kishechnika v norme i pri patologii.

Bifidoflora constitute 85--95 per cent of the large intestine microbiocenosis in children under 1 year of age. Bacteroides are not specific of children under 6 months of age. Lactobacilli, lactic acid streptococci, colon bacilli, enterococci and staphylococci (saprophytic, epidermal) constitute not more than 15 per cent. The predominating group peculiar of eubiosis in adults includes bifidobacteria and bacteroides. Changes in human autoflora are often induced by such factors as impaired ecology, stress, uncontrolled use of antibacterial drugs, radio- and chemotherapy, etc. Dysbacteriosis (first of all lower quantitative contents of bifidoflora) has an unfavourable effect on the intestine secretory function, absorption and certain indices of protein, lipid and mineral metabolism, vitamin synthesizing and fermentative functions and leads to disfunction of the gastrointestinal tract. It is a cause of persisting and relapsing infections in children and adults. High and optimal levels of bifidoflora in the intestine usually prevent the pathogenic action of pathogens. Lysozyme of digestive secretion and secretory immunity with immunoglobulin A prevalence also play an important role in the complicated mechanism of the protective barrier. The use of bacterial preparations such as bifidumbacterin, lactobacterin or bifilact for stabilization and recovery of high bifidoflora levels is indicated in all the cases with impaired microbiocenosis of the intestine.

[Protective properties of moose's milk and perspectives of its use in pediatric gastroenterology]. / Zashchitnye svoistva losinogo moloka i perspektiva ego ispozovaniia v detskoi gastroénterologii.

The authors studied microbe dissemination, lysozyme activity and antacid properties in some samples of native, pasteurized and boiled moose's milk. A relationship was demonstrated between the buffer properties of moose's milk and its lysozyme activity. It is advisable that moose's milk be used in combined therapy and for prevention of gastroenterologic diseases in children.

[Antacid bifilact and its effectiveness in the treatment of chronic gastroduodenitis and ulcer disease in children]. / Antatsidnyi bifilakt i ego éffektivnost' v terapii khronicheskogo gastroduodenita i iazvennoi bolezni u detei.

Antacid bifilact was applied for the first time to the treatment of 30 patients with gastroduodenitis and peptic ulcer. This enabled one to remove the disease clinical manifestations within the shortest time possible, to normalize the acid-forming function of the stomach and upset microecology of the intestine, lysozyme activity of alimentary secretions. The formulation and know how for antacid bifilact, a new dietetic product, are described.