RESUMO
BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture. CASE STUDY: In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm. RESULTS: She was followed conservatively. One month later the CT scan signs of rupture disappeared. CONCLUSION: We must pay attention to this rare but serious adverse event during filgrastim use.
Assuntos
Doadores de Sangue , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Mobilização de Células-Tronco Hematopoéticas/efeitos adversos , Ruptura Esplênica/etiologia , Dor Abdominal , Adulto , Feminino , Filgrastim , Fator Estimulador de Colônias de Granulócitos/efeitos adversos , Transplante de Células-Tronco Hematopoéticas , Humanos , Proteínas Recombinantes/efeitos adversos , Tomografia Computadorizada por Raios XAssuntos
Adenocarcinoma/secundário , Neoplasias Ósseas/secundário , Glomerulonefrite por IGA/etiologia , Metástase Linfática , Síndromes Paraneoplásicas/etiologia , Neoplasias Gástricas/complicações , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico , Adenocarcinoma/cirurgia , Adenocarcinoma/terapia , Neoplasias Ósseas/complicações , Quimiorradioterapia , Terapia Combinada , Edema/etiologia , Glomerulonefrite por IGA/tratamento farmacológico , Glomerulosclerose Segmentar e Focal/tratamento farmacológico , Glomerulosclerose Segmentar e Focal/etiologia , Humanos , Losartan/uso terapêutico , Masculino , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Síndrome Nefrótica/tratamento farmacológico , Síndrome Nefrótica/etiologia , Síndromes Paraneoplásicas/tratamento farmacológico , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/cirurgia , Neoplasias Gástricas/terapiaRESUMO
The central nervous system (CNS) toxicity of fluoroquinolones is well known but usually occurs benign. In the literature, there are a few number of severe CNS toxicity cases related to fluoroquinolones. Levofloxacin is a third-generation fluorinated quinolone antibiotic, is the active levo stereoisomer of ofloxacin, and has one of the most favorable adverse reaction profiles. We describe a case of delirium associated with levofloxacin in a 55-year-old man who was hospitalized in our medical clinic for pneumonia.
