[Acute lymphoblastic leukemia in children. The use of antisera specific for lymphocyte populations in a classification trial]. / Leucoses aigües lymphoblastiques de l'enfant. Utilisation d'antisérums spécifiques des populations lymphocytaires en vue d'un essai de classification.

Mononuclear cells from 14 children with acute lymphoblastic leukaemia (ALL) were studied using several lymphocyte membrane markers: E-rosettes, "active" E-rosettes, surface immunoglobulins, EA-rosettes. The use of these techniques and of three specific heterologous antisera directed against T and B cell antigens enabled the discrimination of three different ALL types according to the stage of cell maturation at which it is likely that neoplastic differention occured: T-cell ALL, pre-thymic cell ALL, and "non-T non-B" cell ALL showing only HLA-DR antigens.

[Ocular localization appearing in a child with acute lymphoblastosis after hematological remission for 18 months]. / Localisation oculaire apparue chez un enfant atteint de lymphoblastose aiguë en rémission hématologique depuis 18 mois.

Case report of a 4-year-old girl in whom a unilateral ocular localization appeared after 1 1/2 year of maintained remission of acute lymphoblastic leukaemia. The evolution of this localization can be divided in three phases: 1. During the first 17 months, an apparent simple relapsing conjunctivitis of the left eye. 2. During the following 5 months, repeated episodes of the left iritis with mydriasis and discolouration of the iris. 3. Finally, left uveitis involving the anterior chamber, with hypopion, hyphaema and glaucoma; the clinical presentation at this stage was suggestive of ocular lymphoblastosis. Radiotherapy to the lesion (total dose, 1 200 rads) was quickly followed by resolution without sequelae. No relapse was observed during the following 30 months, till death. The ocular disease remained the only manifestation of leukaemia during its evolution. A haematological relapse occurred 11 months after cure of the iritis, followed 1 year later by a second, treatment-sensitive relapse, and finally by a third, fatal relapse. The patient survived 5 years 9 months.

[Congenital aplastic anemia, type I]. / Anemie dyserythropoietique congenitale, type I

Case report of a 7 year old girl, anaemic since birth. The anaemia, of variable intensity, is associated with a moderate reticulocytosis. Bone marrow films, show a marked erythroblastosis with conspicuous morphological abnormalities and internuclear chromatin bridges. The erythrocinetic pattern is that of ineffective erythropoiesis. The morphologic features are those of Heimpel and Wendt's type I congenital dyserythropoiesis. The erythrocytes are lysed by some acidified sera, thus showing a membrane anomaly which is unusual in type I. However the characteristics of the lysis are different from those of type II (HEMPAS) erythrocytes.