[Is there dependence between the level of adipocyte fatty acid-binding protein and calcium score in asymptomatic relatives of patients with cardiovascular diseases?]. / Existuje závislost mezi hladinou adipocyte fatty acid binding proteinu a kalciovým skóre u asymptomatických príbuzných pacientu s KVO?

UNLABELLED: The objective of our study was to determine a correlation between the level of adipocyte fatty acid-binding protein (A-FABP) (as a possible link between metabolic syndrome and atherosclerosis), the calcium score (CS) and laboratory parameters, including insulin resistance indices in asymptomatic first degree relatives of patients with cardiovascular diseases. SET AND METHODOLOGY: Examination was conducted in 82 persons (53 male) with the average age of 52.79 ± 9.6. The examinations consisted of anthropometric and physical tests (determination of body weight, height, body mass index - BMI and casual blood pressure measurement), laboratory analysis (uric acid, creatinine, lipid panel, insulin, glucose, C-reactive protein, fibrinogen, glycated hemoglobin, adipocyte fatty acid-binding protein - A-FABP) and determination of insulin resistance indices HOMA and QUICKI. Total calcium score (CS) was determined by the Agatston method without the need to administer a contrast agent. RESULTS: The value of the A-FABP level does not show a statistically significant dependence on the categorised CS or on non-categorised CS values. There is a statistically significant positive dependence of the level of A-FABP on the HOMA index (p = 0.00688) and a statistically significant negative dependence on the QUICKI index (p = 0.0068). The A-FABP level is statistically significantly higher in women (p = 0.048), in elder persons (p = 0.043), and in persons with higher BMI values (p = 0.029). Among continuous variables, statistically significant is the difference in the A-FABP level in relation to age (p = 0.002), creatinine (p = 0.026), insulin (p = 0.005), and BMI (p = 0.031). CONCLUSION: Our study confirmed the correlation of the A-FABP level with insulin resistance indices, BMI, age, gender, and insulin and creatinine levels in a group of asymptomatic first degree relatives of patients with cardiovascular diseases. A-FABP could potentially be a marker when determining the risk of CVD; however, this conclusion requires additional clinical trials.

[The influence of targeted intervention on the incidence of risk factors of cardiovascular diseases at medical staff]. / Vliv cílene intervence na výskyt rizikových faktoru kardiovaskulárních onemocnení u zdravotnických zamestnancu.

INTRODUCTION: The work addresses the targeted intervention of cardiovascular diseases at medical staff. SET AND METHODICS: During 2002-2004 years, within the scope of preventive examination, there was made targeted prevention of risk factors of cardiovascular diseases (CVD) at the big hospital employees at the Centre of preventive care of employees and in the department of preventive cardiology of Ist Internal Clinic of LF UP and FN Olomouc. According to the effective tables, there was stated a CVD risk of these employees. The employees received a personal individual letter which informed them of the level of CVD risk and proposed a targeted intervention of risk factors. The part of the set--427 employees of the average age of 38.93 years (SD 11.39), 69 men (M) of the average age of 40 years (SD 12.47) and 358 women (F) of the average age of 38.7 years (SD 11.18) was examined another time during 2004-2005 years. The methodics of second examination was the same as at the first examination, only the questionnaire was complemented by the questions related to the knowledge of the CVD risk stated at previous examination. RESULTS: There occurred statistically significant decrease of LDL cholesterol in the set (from 2.87 mmol/l to 1.23 mmol/l, p < 0.0001) and BMI decrease (from 24.35 to 24.16, p < 0.05) and at the same time statistically significant increase of total cholesterol (from 5.09 mmol/l to 5.27 mmol/l, p < 0.05) and triglycerides (from 1.27 mmol/l to 3.01 mmol/l, p < 0.0001). There was no significant change in other RFs (BP, WHR, HDL cholesterol, moving activity). The influence on RF of smoking was statistically significant (23 employees quitted smoking, 10 employees started, p < 0.05). 53 F (14.80%) and 3 M (4.34%) know their cardiovascular risk, 235 F (65.64%) and 53 M (76.81%) do not know their cardiovascular risk. CONCLUSION: The work approved the influence of targeted intervention on the incidence of cardiovascular diseases risk factors and at the same time low level of knowledge of one's own individual risk, despite of targeted intervention.