RESUMO
In this prospective study, we tried to evaluate various "humoral tests of malignancy" regarding their efficiency of discriminating between malignancy-related and non-malignant ascites. Fibronectin, total protein, number of cells, LDH, pH, specific gravity and cytology were compared in the ascitic fluid of 51 patients with malignancy-related and 52 patients with non-malignant ascites; patients with tuberculous peritonitis were not included. Ascitic fluid cholesterol was determined in 36 of 51 malignancy-related and in 37 of 52 non-malignant ascites. Cytology and fibronectin were found 100% specific with diagnostic efficiency 87.5% and 94.2% respectively under optimal conditions. Cholesterol was neither sensitive nor specific. It is concluded that fibronectin was a valuable test for malignancy-associated ascites.
Assuntos
Líquido Ascítico/etiologia , Colesterol/análise , Fibronectinas/análise , Líquido Ascítico/sangue , Líquido Ascítico/diagnóstico , Colesterol/sangue , Diagnóstico Diferencial , Fibronectinas/sangue , Humanos , Neoplasias/complicações , Neoplasias/diagnóstico , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e EspecificidadeRESUMO
The phenotypes and allele frequencies of two serum protein systems (GC and C3) were studied in 91 consecutive patients with ulcerative colitis and compared with healthy controls. No significant differences were found as far as GC was concerned. However, significant differences were observed in C3: the C3*F allele and C3FS phenotype were more frequent in patients than in controls.
Assuntos
Colite Ulcerativa/sangue , Complemento C3c/genética , Proteína de Ligação a Vitamina D/genética , Alelos , Tipagem e Reações Cruzadas Sanguíneas , Colite Ulcerativa/genética , Feminino , Frequência do Gene , Humanos , Masculino , Fenótipo , Proteína de Ligação a Vitamina D/sangueRESUMO
The phenotypes and gene frequencies of two serum protein systems (GC, C3) were studied in 238 consecutive patients with peptic ulcer from all over Greece. 173 patients had duodenal ulcer and 65 had gastric ulcer. Healthy Greeks studied previously in our department served as controls. No significant differences were found between the studied groups and the controls as far as GC was concerned. However, significant differences emerged in C3; the C3*F gene was almost twice more common and the C3F phenotype almost three times more frequent in patients than in controls.
