1.
Org Lett
; 3(19): 3009-12, 2001 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11554830
RESUMO
The synthesis of (-)-epibatidine has been accomplished utilizing a highly exo-selective asymmetric hetero Diels-Alder reaction. The key steps employed to transform the resulting bicycle into the natural product include a fluoride-promoted fragmentation and a Hofmann rearrangement. Reaction: see text.