[Effectiveness of radical treatment in infections with antochthonous strains of P. malariae]. / Eficacitatea tratamentului în cura radicala în infectii cu suse autohtone de P. malariae.

The present paper reports on the results obtained in longitudinal serological investigations (indirect immunofluorescence and species homologous antigen) carried out with a review to evaluating the efficiency of the radical treatment in malaria caused by residual autochtonous P. malariae strains. In acute infections the treatment was followed by progressive decrease in the antibody level, tending towards zero in the course of a year; in the latent, asymptomatic infection, antibodies persisted at high levels for several years after the treatment, indicating persistence of the parasite and, hence, inefficiency of the treatment.

[Dynamics of the immune response in a familial focus of toxoplasmosis]. / Dinamica raspunsului imunitar intr-un focar familial de toxoplasmoza

Immunoepidemiological investigations were carried out in a family in which a child with congenital toxoplasmosis was born in 1972. The following were determined: total fluorescent antibodies and their G and M fractions and G and M serum immunoglobulins. The results showed: --the existence of a familial focus if infection with T. gondii, the risk of infection in the course of pregnancy and its consequences on the product of conception; --the normal evolution of the following pregnancy in the presence of anti-T. gondii fluorescent antibodies and the birth of a normal child; --value of the indirect immunofluorescence test for the diagnosis of congenital toxoplasmosis and of the longitudinal immunologic investigation; --determination of the antibody M fraction and serum immunoglobulins did not prove as useful as expected; --persistance of fluorescent antibodies in significant titers over a long period in the absence of a clinical symptomatology or with clinical manifestations of another etiology might lead to a false diagnosis of toxoplasmosis -- hence the necessity of a test for differentiating the carrier of specific antibodies from the toxoplasmosis patient.