Onset and limiting amplitude of yaw instability of a submerged three-tethered buoy.

In this paper the dynamics of a submerged axi-symmetric wave energy converter are studied, through mathematical models and wave basin experiments. The device is disk-shaped and taut-moored via three inclined tethers which also act as a power take-off. We focus on parasitic yaw motion, which is excited parametrically due to coupling with heave. Assuming linear hydrodynamics throughout, but considering both linear and nonlinear tether geometry, governing equations are derived in 6 degrees of freedom (DOF). From the linearized equations, all motions, apart from yaw, are shown to be contributing to the overall power absorption. At higher orders, the yaw governing equation can be recast into a classical Mathieu equation (linear in yaw), or a nonlinear Mathieu equation with cubic damping and stiffness terms. The well-known stability diagram for the classical Mathieu equation allows prediction of onset/occurrence of yaw instability. From the nonlinear Mathieu equation, we develop an approximate analytical solution for the amplitude of the unstable motions. Comparison with regular wave experiments confirms the utility of both models for making relevant predictions. Additionally, irregular wave tests are analysed whereby yaw instability is successfully correlated to the amount of parametric excitation and linear damping. This study demonstrates the importance of considering all modes of motion in design, not just the power-producing ones. Our simplified 1 DOF yaw model provides fundamental understanding of the presence and severity of the instability. The methodology could be applied to other wave-activated devices.

The effect of bed roughness uncertainty on tidal stream power estimates for the Pentland Firth.

Uncertainty affects estimates of the power potential of tidal currents, resulting in large ranges in values reported for sites such as the Pentland Firth, UK. Kreitmair et al. (2019, R. Soc. open sci. 6, 180941. (doi:10.1098/rsos.191127)) have examined the effect of uncertainty in bottom friction on tidal power estimates by considering idealized theoretical models. The present paper considers the role of bottom friction uncertainty in a realistic numerical model of the Pentland Firth spanned by different fence configurations. We find that uncertainty in removable power estimates resulting from bed roughness uncertainty depends on the case considered, with relative uncertainty between 2% (for a fully spanned channel with small values of mean roughness and input uncertainty) and 44% (for an asymmetrically confined channel with high values of bed roughness and input uncertainty). Relative uncertainty in power estimates is generally smaller than (input) relative uncertainty in bottom friction by a factor of between 0.2 and 0.7, except for low turbine deployments and very high mean values of friction. This paper makes a start at quantifying uncertainty in tidal stream power estimates, and motivates further work for proper characterization of the resource, accounting for uncertainty inherent in resource modelling.

The effect of uncertain bottom friction on estimates of tidal current power.

Uncertainty affects estimates of the power potential of tidal currents, resulting in large ranges in values reported for a given site, such as the Pentland Firth, UK. We examine the role of bottom friction, one of the most important sources of uncertainty. We do so by using perturbation methods to find the leading-order effect of bottom friction uncertainty in theoretical models by Garrett & Cummins (2005 Proc. R. Soc. A 461, 2563-2572. (doi:10.1098/rspa.2005.1494); 2013 J. Fluid Mech. 714, 634-643. (doi:10.1017/jfm.2012.515)) and Vennell (2010 J. Fluid Mech. 671, 587-604. (doi:10.1017/S0022112010006191)), which consider quasi-steady flow in a channel completely spanned by tidal turbines, a similar channel but retaining the inertial term, and a circular turbine farm in laterally unconfined flow. We find that bottom friction uncertainty acts to increase estimates of expected power in a fully spanned channel, but generally has the reverse effect in laterally unconfined farms. The optimal number of turbines, accounting for bottom friction uncertainty, is lower for a fully spanned channel and higher in laterally unconfined farms. We estimate the typical magnitude of bottom friction uncertainty, which suggests that the effect on estimates of expected power lies in the range -5 to +30%, but is probably small for deep channels such as the Pentland Firth (5-10%). In such a channel, the uncertainty in power estimates due to bottom friction uncertainty remains considerable, and we estimate a relative standard deviation of 30%, increasing to 50% for small channels.

Transverse motion instability of a submerged moored buoy.

Wave energy converters and other offshore structures may exhibit instability, in which one mode of motion is excited parametrically by motion in another. Here, theoretical results for the transverse motion instability (large sway oscillations perpendicular to the incident wave direction) of a submerged wave energy converter buoy are compared to an extensive experimental dataset. The device is axi-symmetric (resembling a truncated vertical cylinder) and is taut-moored via a single tether. The system is approximately a damped elastic pendulum. Assuming linear hydrodynamics, but retaining nonlinear tether geometry, governing equations are derived in six degrees of freedom. The natural frequencies in surge/sway (the pendulum frequency), heave (the springing motion frequency) and pitch/roll are derived from the linearized equations. When terms of second order in the buoy motions are retained, the sway equation can be written as a Mathieu equation. Careful analysis of 80 regular wave tests reveals a good agreement with the predictions of sub-harmonic (period-doubling) sway instability using the Mathieu equation stability diagram. As wave energy converters operate in real seas, a large number of irregular wave runs is also analysed. The measurements broadly agree with a criterion (derived elsewhere) for determining the presence of the instability in irregular waves, which depends on the level of damping and the amount of parametric excitation at twice the natural frequency.

Exploiting coumarin-6 as ancillary ligands in 1,10-phenanthroline Ir(iii) complexes: generating triplet photosensitisers with high upconversion capabilities.

A series of new Ir(iii) complexes incorporating 3-(2-benzothiazolyl)-7-(diethylamino)coumarin (coumarin 6) and ethynylpyrene (EP) functionalised 1,10-phenanthroline (phen) were developed. [Ir(iii)(coumarin 6)2(3-EP-phen)](PF6) (Ir-3) proved to be the most promising material in triplet photosensitising applications. Highly absorbing at λ = 485 nm (ε = 1.31 × 105 M-1 cm-1), it exhibits high upconversion and singlet oxygen quantum yields (ΦUC = 27.5%, ΦΔ = 81.5%) and an exemplary upconversion capability (η = 3.60 × 106 M-1 cm-1).

Flow through a very porous obstacle in a shallow channel.

A theoretical model, informed by numerical simulations based on the shallow water equations, is developed to predict the flow passing through and around a uniform porous obstacle in a shallow channel, where background friction is important. This problem is relevant to a number of practical situations, including flow through aquatic vegetation, the performance of arrays of turbines in tidal channels and hydrodynamic forces on offshore structures. To demonstrate this relevance, the theoretical model is used to (i) reinterpret core flow velocities in existing laboratory-based data for an array of emergent cylinders in shallow water emulating aquatic vegetation and (ii) reassess the optimum arrangement of tidal turbines to generate power in a tidal channel. Comparison with laboratory-based data indicates a maximum obstacle resistance (or minimum porosity) for which the present theoretical model is valid. When the obstacle resistance is above this threshold the shallow water equations do not provide an adequate representation of the flow, and the theoretical model over-predicts the core flow passing through the obstacle. The second application of the model confirms that natural bed resistance increases the power extraction potential for a partial tidal fence in a shallow channel and alters the optimum arrangement of turbines within the fence.

Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum.

Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium parasites within the mosquito, with the aim of preventing malaria transmission from one infected individual to another. Different vaccine platforms, mainly protein-in-adjuvant formulations delivering the leading candidate antigens, have been developed independently and have reported varied transmission-blocking activities (TBA). Here, recombinant chimpanzee adenovirus 63, ChAd63, and modified vaccinia virus Ankara, MVA, expressing AgAPN1, Pfs230-C, Pfs25, and Pfs48/45 were generated. Antibody responses primed individually against all antigens by ChAd63 immunization in BALB/c mice were boosted by the administration of MVA expressing the same antigen. These antibodies exhibited a hierarchy of inhibitory activity against the NF54 laboratory strain of P. falciparum in Anopheles stephensi mosquitoes using the standard membrane feeding assay (SMFA), with anti-Pfs230-C and anti-Pfs25 antibodies giving complete blockade. The observed rank order of inhibition was replicated against P. falciparum African field isolates in A. gambiae in direct membrane feeding assays (DMFA). TBA achieved was IgG concentration dependent. This study provides the first head-to-head comparative analysis of leading antigens using two different parasite sources in two different vector species, and can be used to guide selection of TBVs for future clinical development using the viral-vectored delivery platform.

Energy expenditure in rock/pop drumming.

Despite the vigorous nature of rock/pop drumming, there are no precise data on the energy expenditure of this activity. The aim of this study was to quantify the energy cost of rock/pop drumming. Fourteen male drummers (mean±SD; age 27±8 yrs.) completed an incremental drumming test to establish the relationship between energy expenditure and heart rate for this activity and a ramped cycle ergometer test to exhaustion as a criterion measure for peak values (oxygen uptake and heart rate). During live concert performance heart rate was continuously measured and used to estimate energy expenditure (from the energy expenditure vs. heart rate data derived from the drumming test). During concert performance, estimated energy expenditure (mean±SD) was 623±168 kcal.h⁻¹ (8.1±2.2 METs) during performances of 38.6±15.6 min, and drummers achieved a peak heart rate of 186±16 b.min⁻¹. During the drumming test participants attained 78.7±8.3% of the cycle ergometer peak oxygen uptake. Rock/pop drumming represents a relatively high-intensity form of physical activity and as such involves significant energy expenditure. Rock/pop drumming should be considered as a viable alternative to more traditional forms of physical activity.

Energy potential of a tidal fence deployed near a coastal headland.

Enhanced tidal streams close to coastal headlands appear to present ideal locations for the deployment of tidal energy devices. In this paper, the power potential of tidal streams near an idealized coastal headland with a sloping seabed is investigated using a near-field approximation to represent a tidal fence, i.e. a row of tidal devices, in a two-dimensional depth-averaged numerical model. Simulations indicate that the power extracted by the tidal fence is limited because the flow will bypass the fence, predominantly on the ocean side, as the thrust applied by the devices increases. For the dynamic conditions, fence placements and headland aspect ratios considered, the maximum power extracted at the fence is not related in any obvious way to the local undisturbed kinetic flux or the natural rate of energy dissipation due to bed friction (although both of these have been used in the past to predict the amount of power that may be extracted). The available power (equal to the extracted power net of vertical mixing losses in the immediate wake of devices) is optimized for devices with large area and small centre-to-centre spacing within the fence. The influence of energy extraction on the natural flow field is assessed relative to changes in the M2 component of elevation and velocity, and residual bed shear stress and tidal dispersion.

The oxygen uptake kinetic response to moderate intensity exercise in overweight and non-overweight children.

OBJECTIVE: To compare the phase II oxygen uptake time constant (τV'O(2)) and V'O(2) mean response time (V'O(2)MRT) in overweight (OW) and non-OW (NO) children during moderate intensity exercise. DESIGN: Between subjects where participants completed a maximal ramp exercise test on an electromagnetically braked cycle ergometer to determine peak V'O(2) (V'O(2peak)) and gas exchange threshold (GET). Gas exchange was measured breath-by-breath using a mass spectrometer. On subsequent visits, 6 square-wave transitions (2 per day) from 0 W to 90% GET were completed. Individual phase II τV'O(2) and V'O(2)MRTs were estimated from time aligned average V'O(2) traces. SUBJECTS: Eleven OW (11.8±0.4 years) and 12 NO (11.9±0.4 years) children were recruited to the study. The OW group was significantly heavier (62.9±9.7 vs 39.4±5.8 kg, P<0.001), taller (1.58±0.05 vs 1.47±0.07 m, P<0.001) and had a higher body mass index (25.8±3.4 vs 18.3±1.8 kg m(-2), P<0.001). RESULTS: Both τV'O(2) (30.2±9.6 vs 22.8±7.1 s, P<0.05) and V'O(2)MRT (43.5±10.7 vs 36.3±5.3 s, P<0.05) were significantly slower in OW compared with NO children; absolute V'O(2peak) was higher in the OW compared with NO group (2.23±0.04 vs 1.74±0.04 l min(-1), P<0.05); mass relative V'O(2peak) was lower in OW compared with NO children (35.9±8.3 vs 43.8±6.2 ml kg(-1) min(-1), P<0.05); allometrically scaled V'O(2peak) was similar between OW and NO groups whether relative to body mass(0.67) (139.8±29.1 vs 147.2±23.9 ml kg(-67) min(-1)) or stature(3) (576.0±87.2 vs 544.9±84.9 ml m(-3) min(-1)) (P>0.05); absolute V'O(2) at GET was similar between OW and NO groups (0.94±0.24 vs 0.78±0.27 l min(-1), P>0.05); GET expressed as percentage of V'O(2peak) was similar between the groups (42.0±0.1 vs 44.8±0.1%, P>0.05). CONCLUSION: These findings demonstrate impairment in the factors determining V'O(2) kinetics in OW children at a relatively young age. Furthermore, assessment of cardiorespiratory fitness using peak exercise values is likely to be misleading and not useful when designing exercise programmes for OW children.

Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmodium falciparum.

Naturally acquired immunity to Plasmodium falciparum's asexual blood stage reduces parasite multiplication at microscopically detectable densities. The effect of natural immunity on initial prepatent parasite multiplication during the period following a new infection has been uncertain, contributing to doubt regarding the utility of experimental challenge models for blood-stage vaccine trials. Here we present data revealing that parasite multiplication rates during the initial prepatent period in semi-immune Gambian adults are substantially lower than in malaria-naive participants. This supports the view that a blood-stage vaccine capable of emulating the disease-reducing effect of natural immunity could achieve a detectable effect during the prepatent period.

New candidate vaccines against blood-stage Plasmodium falciparum malaria: prime-boost immunization regimens incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1.

Although merozoite surface protein 1 (MSP-1) is a leading candidate vaccine antigen for blood-stage malaria, its efficacy in clinical trials has been limited in part by antigenic polymorphism and potentially by the inability of protein-in-adjuvant vaccines to induce strong cellular immunity. Here we report the design of novel vectored Plasmodium falciparum vaccines capable of overcoming such limitations. We optimized an antigenic insert comprising the four conserved blocks of MSP-1 fused to tandemly arranged sequences that represent both allelic forms of the dimorphic 42-kDa C-terminal region. Inserts were expressed by adenoviral and poxviral vectors and employed in heterologous prime-boost regimens. Simian adenoviral vectors were used in an effort to circumvent preexisting immunity to human adenoviruses. In preclinical studies these vaccines induced potent cellular immune responses and high-titer antibodies directed against MSP-1. The antibodies induced were found to have growth-inhibitory activity against dimorphic allelic families of P. falciparum. These vectored vaccines should allow assessment in humans of the safety and efficacy of inducing strong cellular as well as cross-strain humoral immunity to P. falciparum MSP-1.

Blood-stage malaria vaccines - recent progress and future challenges.

Plasmodium falciparum malaria is a major global health problem, responsible for up to 1 million deaths each year. Major efforts have been made to develop an effective vaccine against this disease, to reduce the associated morbidity and mortality. There has already been considerable progress, with the first vaccine against the pre-erythrocytic stages of P. falciparum now en route to licensure. There remains, however, a strong scientific rationale for the development of a highly effective additional vaccine component against the blood stages of the parasite, which could be deployed in conjunction with partially effective control measures against the pre-erythrocytic stages. Here, recent progress in the clinical development of blood-stage vaccines is reviewed, including methods of antigen selection, the limitations of in-vitro assays for selecting vaccines for clinical development, and the results of recently published clinical trials. This review seeks to summarize recent developments in our understanding of immunity to blood-stage parasites, as well as the relevant key advances made in vaccine technologies over the last decade. The future challenges that face this field of vaccine research are also described.

Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.

Human adenovirus serotype 5 (AdH5) vector vaccines elicit strong immune responses to the encoded antigen and have been used in various disease models. We designed AdH5 vectors expressing antigen under the control of a human cytomegalovirus (HCMV) immediate-early promoter containing its intron A sequence. The transcriptional levels of antigen and immune responses to antigen for vectors with the HCMV promoter with the intron A sequence (LP) were greater than those for AdH5 vectors using the HCMV promoter sequence without intron A (SP). We compared an E1E3-deleted AdH5 adenoviral vector, which affords more space for insertion of foreign sequences, and showed it to be as immunogenic as an E1-deleted AdH5 vector. Neutralizing antibodies to AdH5 limit the efficacy of vaccines based on the AdH5 serotype, and simian adenoviral vectors offer an attractive option to overcome this problem. We constructed E1E3-deleted human and simian adenoviral vectors encoding the pre-erythrocytic-stage malarial antigen Plasmodium berghei circumsporozoite protein. We compared the immunogenicity and efficacy of AdC6, a recombinant simian adenovirus serotype 6 vector, in a murine malaria model to those of AdH5 and the poxviral vectors MVA and FP9. AdC6 induced sterile protection from a single dose in 90% of mice, in contrast to AdH5 (25%) and poxviral vectors MVA and FP9 (0%). Adenoviral vectors maintained potent CD8(+) T-cell responses for a longer period after immunization than did poxviral vectors and mainly induced an effector memory phenotype of cells. Significantly, AdC6 was able to maintain protection in the presence of preexisting immunity to AdH5.

Influence of pacing strategy on oxygen uptake during treadmill middle-distance running.

The oxygen uptake (VO2) attained during a constant speed 800-m pace trial on a treadmill is less than the maximal VO2 (VO2max) in male middle-distance runners with a high VO2max (i.e., > 65 ml x kg (-1) x min (-1)). We therefore investigated whether the VO2 attained was influenced by the pacing strategy adopted. Eight male middle-distance runners (age 25.8 +/- 3.3 years; height 1.78 +/- 0.10 m; mass 67.8 +/- 4.7 kg) with a personal best 800-m time of 112.0 +/- 3.3 s volunteered to participate. Subjects undertook a speed ramped progressive test to determine VO2max and three 800-m pace runs to exhaustion all in a randomised order. The three 800-m pace runs included constant speed, acceleration, and race simulation runs. Oxygen uptake was determined throughout each test using 15-s Douglas bag collections. Following the application of a 30-s rolling average, the highest VO2 during the progressive test (i.e., VO2max) and the highest VO2 during the 800-m pace runs (i.e., VO2peak) were compared. For the eight runners, VO2max was 67.2 +/- 4.3 ml x kg (-1) x min (-1) x VO2peak was 60.1 +/- 5.1 ml x kg (-1) x min (-1), 61.1 +/- 5.2 ml x kg (-1) x min (-1), and 62.2 +/- 4.9 ml x kg (-1) x min (-1), yielding values of 89.3 +/- 2.4 %, 90.8 +/- 2.8 %, and 92.5 +/- 3.1 % VO2max for the constant speed, acceleration and race simulation runs, respectively. Across runs, repeated measures ANOVA revealed a significant effect (p = 0.048). Trend analysis identified a significant linear trend (p = 0.025) with the % VO2max attained being higher for the acceleration run than the constant speed run, and higher still for the race simulation run. These results demonstrate that in middle-distance runners a) pacing strategy influences the VO2 attained, with a race simulation run elevating the VO2 attained compared with other pacing strategies, and b) regardless of pacing strategy the VO2 attained in an 800-m pace run on a treadmill is less than VO2max.

The oxygen uptake response of sprint- vs. endurance-trained runners to severe intensity running.

We compared the oxygen uptake (VO2) response of sprint- and endurance-trained runners for an exhaustive square wave run lasting approximately 2 minutes. Six sprinters and six middle- and long-distance runners each performed two exhaustive square wave runs lasting approximately 2 min and two exhaustive ramp tests. VO2 was determined breath-by-breath (QP9000; Morgan Medical, Rainham, UK) and averaged across the two repeats of each test; for the square wave test, the averaged VO2 response (excluding the first 15 s) was then modelled using a monoexponential function. Both VO2peak for the ramp test (67.5+/-3.3 vs. 54.5+/-8.5 mlxkg(-1)xmin(-1); P= 0.006) and the asymptotic VO2 for the square wave run (59.6+/-2.7 vs. 50.7+/-4.6 mlxkg(-1)xmin(-1); P= 0.002) were higher for the endurance than for the sprint group. However, as a percentage of VO2peak, this asymptotic VO2 did not differ between the groups (90.1+/-3.2% (endurance) vs. 96.2+/-9.0% (sprint); P= 0.145). Across all 12 subjects, the %VO2peak attained in the square wave run was negatively correlated with VO2peak (Pearson's r= -0.811, P= 0.001). We conclude that VO2max is more important than training history as a determinant of the %VO2max attained in exhaustive square wave running lasting approximately 2 min.

The VO2 response for an exhaustive treadmill run at 800-m pace: a breath-by-breath analysis.

Recent research in which data were averaged over 10 or 30 s suggests that the VO(2) response of aerobically fit individuals plateaus below VO(2 max) in an exhaustive square-wave run lasting approximately 2 min. To investigate this phenomenon we examined the breath-by-breath VO(2) response of trained runners to an exhaustive treadmill run at 800 m pace. Eight male competitive runners completed two treadmill tests on separate days: a ramp test to exhaustion and an exhaustive square-wave run at 800-m pace. For the ramp test, the breath-by-breath data were smoothed with a 15-s moving average and the highest of the smoothed values was taken as VO(2 peak) [mean (SD): 68.9 (5.6) ml kg(-1) min(-1)]. For the square-wave, the breath-by-breath data were interpolated to give one value per second and modelled using a monoexponential function. Following a delay of 11.2 (1.5) s, VO(2) increased quickly [phase-2 time constant of 10.7 (2.7) s] towards an asymptote that represented just 85 (6)% of VO(2 peak) from the ramp test. Expressed in ml kg(-1) min(-1), this asymptote was independent of VO(2 peak) (r=0.04, P=0.94). However, as a percentage of VO(2 peak) it was negatively correlated with VO(2 peak) itself (r=-0.96, P<0.001). It is concluded that in an exhaustive square-wave treadmill run lasting approximately 2 min the VO(2) of aerobically fit runners increases quickly to plateau at a level that is lower than, but independent of, VO(2max).

The VO2 response to exhaustive square wave exercise: influence of exercise intensity and mode.

We investigated the oxygen uptake ( VO(2)) response to exhaustive square wave exercise of approximately 2, 5 and 8 min duration in cycling and running. Nine males completed a ramp test and three square wave tests on a motorised treadmill and the same four tests on a cycle ergometer, throughout which gas exchange was assessed (Douglas bag method). The peak VO(2) from the ramp test was higher for running than for cycling [mean (SD): 58.4 (2.8) vs. 55.9 (3.7) ml.kg(-1).min(-1); P=0.04]. However VO(2max) (defined as the highest VO(2) achieved in any of the four tests) did not differ between running and cycling [60.0 (2.9) vs. 58.5 (3.3) ml.kg(-1).min(-1); P=0.15]. The peak VO(2) was similar ( P>0.1) for the 5 and 8 min square wave tests [98.5 (1.8) and 99.2 (2.3) % VO(2max) for running; 97.0 (4.2) and 97.5 (2.0) % VO(2max) for cycling] but lower ( P<0.001) for the 2-min test [91.8 (2.5) and 89.9 (5.5) % VO(2max) for running and cycling respectively]. VO(2) increased over the final two 30-s collection periods of the 2-min test for cycling [Delta VO(2)=0.18 (0.15) l.min(-1); P<0.01] but not running [Delta VO(2)=0.00 (0.09) l.min(-1); P=0.98]. We conclude that in the aerobically fit the peak VO(2) for square wave running or cycling at an intensity severe enough to result in exhaustion in approximately 2 min is below VO(2max). In running, VO(2) plateaus at this sub-maximal rate.

The management of constipation in people with advanced cancer.

Constipation represents a significant problem for people with advanced cancer. It ranks in the top three most uncomfortable symptoms experienced, causing pain and anorexia that ultimately result in misery. The negative impact upon the quality of life of the patient and their carers is significant. The key to the provision of effective care lies in the informed application of the nursing process, underpinned by a sound knowledge base in relation to the management of constipation. Theoretical knowledge enables appropriate preventative interventions to be planned in collaboration with other members of the multidisciplinary team. When preventative measures are not applied or are unsuccessful, informed assessment and care planning enables appropriate interventions to be applied in order to resolve constipation. This article will discuss the causes and management of constipation. The discussion focuses on assessment, setting goals with the patient and their carers, planning appropriate nursing interventions to support medical interventions and evaluating clinical outcomes.

Performance of a psychomotor skill following rest, exercise at the plasma epinephrine threshold and maximal intensity exercise.

The purpose of this study was to examine the effect of exercising at the epinephrine threshold and at Maximum Power Output on the performance of a skill that requires both decision-making and motor performance. Participants (N=12) undertook an incremental test to exhaustion from which their epinephrine threshold and Maximum Power Output were calculated. They were then examined on a soccer skill test following rest and exercise that was previously determined to elicit their epi nephrine threshold and Maximum Power Output. The soccer test examined the participants' speed and accuracy of response. Speed of response was measured by voice reaction time and whole body reaction time. No significant effects of exercise were shown for any of the variables. The need for further research using more complex skill tests and the use of discontinuous exercise protocols, rather than continuous ones, is recommended.