Gender effects on high frequency distortion product otoacoustic emissions in humans.

OBJECTIVE: Gender has been reported to affect many tests of the auditory system, including distortion product otoacoustic emission (DPOAE) group delay and level when elicited with lower frequency stimuli (<8 kHz). Using custom equipment, the effect of gender on DPOAEs at higher frequencies was explored. It is expected that differences in group delay reported at very low frequencies (e.g., 0.78 Hz) will not be replicated at higher frequencies. Additionally, it was hypothesized that female subjects would display larger-level DPOAEs at higher frequencies, based on evidence that female subjects tend to have larger emissions when elicited with lower frequency stimuli. DESIGN: DPOAEs were measured in 37 subjects (20 females and 17 males) with normal behavioral thresholds, middle ear function, and present acoustic reflexes at 1 kHz with contralateral stimulation. Behavioral thresholds were measured through 16 kHz using Békèsy tracking. Ratio and frequency sweeps were used to calculate DPOAE group delay and measure DPOAE levels, respectively. Ratio sweeps were obtained at f2 frequencies of 1, 2, 4, 8, 10, 12, 14, and 16 kHz, with L1 = 60 and L2 = 45 dB SPL, with the ratio (f2/f1) varied from 1.11 to 1.3. Frequency sweeps were measured with L1 = 60 and L2 = 45 dB SPL and an f2/f1 of 1.2 at discrete f2 frequencies between 1 and 16 kHz. Data were subjected to repeated-measures analysis of variance. RESULTS: Significant frequency-by-gender interactions were found for group delay (for data from 1 to 8 kHz) and level (for data from 9 to 15 kHz). The frequency-by-gender interaction and the main effect of gender were not significant for the behavioral results. CONCLUSIONS: Gender-based norms for auditory-evoked potentials measures are standard in clinical settings. The results of the present study, in agreement with previous studies, indicate that significant interactions exist between gender and DPOAE group delay values in the lower frequencies, and between gender and DPOAE levels at the higher frequencies. To reach the goal of using high frequency DPOAEs in clinical protocols, such as for auditory neuropathy/dys-synchrony diagnosis and ototoxicity monitoring, DPOAEs elicited with conventional and higher frequency stimuli must be understood, including the role of gender to determine if an effect on clinical protocols would exist.

Distortion-product otoacoustic emissions measured at high frequencies in humans.

Distortion-product otoacoustic emissions (DPOAEs) elicited with stimulus frequencies less than or equal to 8 kHz have been used in hearing clinics to assess whether the middle ear and cochlea are normal, but high-frequency hearing (>4 kHz) is most vulnerable to cochlear pathology. It might prove useful to measure DPOAEs with even higher frequency stimuli (>8 kHz), but there have been few reports of such studies in humans. DPOAEs have been measured in other mammals to the upper range of hearing sensitivity. The purpose of this study was to compare some characteristics of DPOAEs in human subjects elicited with high-frequency stimuli with those that have been extensively measured with lower-frequency stimuli. The primary goal was to establish if the same phenomenon responsible for the behavior of low-frequency DPOAEs is responsible for the behavior of high-frequency DPOAEs. Specifically, the DPOAE level with stimuli varied from 2 to 20 kHz, growth functions of DPOAEs, effects of varying the primary frequency ratio (f2/f1) on the DPOAE level, and DPOAE group delay were determined. Because the behaviors appeared to vary smoothly with stimulus frequency, the study suggests that emissions measured from 2 to 20 kHz were the product of the same biological process.

Repeatability of high-frequency thresholds.

High-frequency (10, 12, 14, 16, and 18 kHz) thresholds were obtained for each ear of 50 young adults having normal low-frequency hearing across four test sessions separated by at least 1, but no more than 2, weeks using a Beltone 2000 audiometer. The threshold differences between each possible test session comparison (N = 6) were not significantly (p greater than 0.05) different for ear, test session comparison, or frequency. Overall, intrasubject high-frequency thresholds were found to be repeatable and within a clinically acceptable range of +/- 10 dB for at least 94% of the ears, regardless of test session comparison and frequency.