[The state of lipid peroxidation and antioxidant protection system in parietal cells under experimental chronic atrophic gastritis development].

The lipid peroxidation state and the system functioning of antioxidant protection in parietal cells under rat chronic atrophic gastritis development was investigated. It was detected that the compensatory increase of superoxide dismutase and catalase activity did not affect the lipoperoxidation process and this resulted in accumulation of toxic TBA reactive substances and diene conjugates during the whole stages of the experimental pathology development. It was shown that the reserved power of the glutathione antioxidant system is sufficient to provide adoptable response in the acute period of the disease owing to increasing intracellular found of the reduced glutathione, but it is insufficient to prevent its decreasing in parietal cells in case of the chronic atrophic gastritis development. Our findings suggest that glutathione system is involved in processes of gastric atrophy. The obtained results testify about considerable system dysfunctions of lipid peroxidation and the antioxidant protection in processes of the rat experimental atrophic gastritis development.

[Signal transudation pathways in parietal cells of the gastric mucosa in experimental stomach ulcer].

The goal of the presented work was the research of signal transduction mechanism in the rat gastric parietal cells under stomach ulcer conditions. In these cells activation of adenylate cyclase (increase of cAMP level and proteinkinase A activity) and phosphoinositide (increases [Ca2+]i; cGMP and phoshatidylinocitole levels; proteinkinase C, proteinkinase G, and calmodulin-dependent-proteinkinase activity) of signals pathway was shown. An increase of plasma membrane phospholipids (PC, PS, PE, PI, LPC) level was shown. Under conditions of influence of the stress factor the membran enzymes activity (H+, K+ -ATPase, 5'-AMPase, Na+, K+ -ATPase, Ca2+, Mg2+ -ATPase and H+, K+ -ATPase) was considerably increased. The intensification of lipid peroxidation processes in rats was demonstrated.

[Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats].

The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology--ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids' hydrolyzing enzyme--phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.

[The use of bee and plant products in the treatment and rehabilitation of subjects exposed to the effect of ionizing radiation]. / Vykorystannia apifitoproduktiv u likuvannia ta reabilitatsiï osib, iaki zaznaly vplyvu ionizuiuchoho vyprominiuvannia.

The necessity is substantiated for use of apiphytoproducts in patients with duodenal ulcer who had become victims of Chernobyl accident. Apiphytoproducts were found out to accelerate the natural elimination of cesium radionuclides from the body, to normalize the indices for lipid peroxidation; they can be used on a monotherapy basis or combined with antisecretory or anti-Helicobacter drug preparations.

[The characteristics of the lipid peroxidation status and the activity of the main antioxidative enzymes in patients with duodenal peptic ulcer who took part in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. / Osoblyvosti stanu perekysnoho okyslennia lipidiv ta aktyvnist' osnovnykh antyoksydantnykh fermentiv u khvorykh na vyrazkovu khvorobu dvanadtsiatypaloï kyshky, iaki braly uchast' u likvidatsiï naslidkiv avariï na ChAES.

Results are submitted of investigations designed to study processes of lipid peroxidation and activity of chief antioxidant enzymes in those patients with duodenal ulcer who took part in the elimination of the effects of the Chernobyl accident. The above contingent of examinees displayed activation of lipid peroxidation (accumulation of conjugated dienes, keto-dienes, malonic dialdehyde) and decline in the activity of superoxide-dismutase, catalase. The results obtained attest to the need for using antioxidants in a complex therapy of patients with peptic ulcer, who have come to be exposed to ionizing radiation.