[Effect of acetyl-CoA C-acyltransferase inhibitor trimetazidine on parameters of global and local systolic and diastolic functions of left ventricular myocardium in patients with combined postinfarction ischemic syndrome]. / Vliianie 3-KAT ingibitora trimetazidina na pokazateli global'noi i regional'noi sistolicheskoi i diastolicheskoi funktsii miokarda levogo zheludochka u bol'nykh s sochetannym postinfarktnym ishemicheskim sindromom.

AIM: To assess effect of trimetazidine on global and regional systolic and diastolic left ventricular function in patients with combined postinfarction ischemic syndrome. MATERIAL: Patients (n=32) with healed myocardial infarction and signs of global systolic (ejection fraction 38,5+/-2,7%) and diastolic (EIA=0,88+/-0,03) left ventricular dysfunction confirmed by Doppler echocardiography. METHODS: Regional systolic and diastolic function was assessed by dobutamine stress echocardiography with Doppler tissue imaging before and after 3 months during which the patients received 60 mg/day of trimetazidine. RESULTS: The segments with hibernating myocardium were found in every patient. These segments along with segments with scars displayed greatest degree of local systolic and diastolic dysfunction and because of their prevalence made significant contribution to the setting of global diastolic dysfunction. Improvement of global diastolic function at rest after trimetazidine was associated with decrease of total number of ischemic segments (from 80 to 67%) especially of those with hibernation (from 61 to 46%). CONCLUSION: The hibernating myocardium was most sensitive to metabolic intervention and its presence after myocardial infarction predicted improvement after drug treatment of not only systolic but also diastolic left ventricle dysfunction. Restoration of function of hibernating myocardium turned out to be possible not only after myocardial revascularization but also after medical therapy.

[Reactions of the circulatory system to static load in athletes and persons less well trained]. / Reaktsii sistemy krovoobrashcheniia na staticheskuiu nagruzku u sportsmenov i malotrenirovannykh lits.

Different cardiovascular responses were assessed in untrained men (1 group) and sportsmen (2 group). The 2 group responses were more economic due to effective vascular reactions, whereas in the 1 group the increase of blood flow during exercise was provided ba cardiac output and to a lesser extent by vascular reactions. Physiological value of the responses and vegetative prognostic criteria of fatigue limiting physical work, are discussed.