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1.
BMC Genet ; 17: 17, 2016 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-26738630

RESUMO

BACKGROUND: The oxytocin (OT) system is known to be implicated in the regulation of complex social behavior, particularly empathy and parenting. The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations. RESULTS: These data were compared with each other and with 14 samples from the corresponding regions retrieved from the 1000 Genomes database. Low level of heterozygosity was observed for both SNPs in all populations in this study (rs53576: Catalonian, Hobs = 0.413; Hadza, Hobs = 0.556; sr2254698: Khanty-Mansi, Hobs = 0.250; Datoga, Hobs = 0.550). The amount of variance due to regional variability was almost equal for both SNPs (rs53576: FRT = 0.086, rs2554298: FRT = 0.072), whereas variance for the population level of variability was twice bigger for rs2554298 (rs53576: FST = 0.127, rs2554298: FST = 0.162). Pairwise coefficients of fixation demonstrate that the Hadza were well differentiated from other African populations except of Datoga, the Datoga were weakly differentiated from other African origin populations, the Ob Ugric people were extremely differentiated from all other populations. Catalans were extremely differentiated of Asian populations. CONCLUSIONS: It is hypothesized on the base of spatial distribution of the evolutionary novel A alleles of the both OXTR gene loci, that the spread of alleles of rs22542298 and rs53376 SNPs may be associated to some extant with manipulation of parental investment in humans.


Assuntos
Polimorfismo de Nucleotídeo Único , Receptores de Ocitocina/genética , Adolescente , Adulto , África , Idoso , Ásia , Cultura , Europa (Continente) , Feminino , Frequência do Gene , Humanos , Masculino , Pessoa de Meia-Idade , Filogeografia , Grupos Raciais/genética , Caracteres Sexuais , Adulto Jovem
2.
PLoS One ; 10(8): e0136208, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26291982

RESUMO

The androgen receptor (AR) gene polymorphism in humans is linked to aggression and may also be linked to reproduction. Here we report associations between AR gene polymorphism and aggression and reproduction in two small-scale societies in northern Tanzania (Africa)--the Hadza (monogamous foragers) and the Datoga (polygynous pastoralists). We secured self-reports of aggression and assessed genetic polymorphism of the number of CAG repeats for the AR gene for 210 Hadza men and 229 Datoga men (aged 17-70 years). We conducted structural equation modeling to identify links between AR gene polymorphism, aggression, and number of children born, and included age and ethnicity as covariates. Fewer AR CAG repeats predicted greater aggression, and Datoga men reported more aggression than did Hadza men. In addition, aggression mediated the identified negative relationship between CAG repeats and number of children born.


Assuntos
Agressão , Polimorfismo Genético , Receptores Androgênicos/genética , Reprodução , Adolescente , Adulto , Idoso , Criança , Família , Humanos , Masculino , Casamento , Pessoa de Meia-Idade , Tanzânia/etnologia , Repetições de Trinucleotídeos , Adulto Jovem
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