RESUMO
The antiischemic properties of the new antioxidant drug enoxifol, representing a derivative of N9-imidazo[1,2-a]benzimidazole, was studied in rats on the models of a double-vessel occlusion of common carotid arteries under normal conditions and on the background of irradiation. In addition, we studied the effect of enoxifol on the rehabilitation of experimental animals in the early reperfusion period after total brain ischemia.
Assuntos
Antioxidantes/farmacologia , Benzimidazóis/farmacologia , Isquemia Encefálica/tratamento farmacológico , Animais , Antioxidantes/uso terapêutico , Arteriopatias Oclusivas/complicações , Comportamento Animal/efeitos dos fármacos , Benzimidazóis/uso terapêutico , Isquemia Encefálica/etiologia , Isquemia Encefálica/psicologia , Doenças das Artérias Carótidas/complicações , Cognição/efeitos dos fármacos , Lesões por Radiação/complicações , Ratos , Taxa de SobrevidaRESUMO
Global cerebral ischemia-reperfusion was modeled by thermocoagulation of the vertebrobasilar arteries followed by occlusion of both carotid arteries. Behavioral parameters, neurological status, and mnesic functions in rats were studied during the recovery period. It is concluded that this model of ischemia is reproducible and can be used for studying ischemia-reperfusion damages to the brain.