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Proc Natl Acad Sci U S A ; 77(2): 866-9, 1980 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-6987669

RESUMO

The transcribing activity of DNA-dependent RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) from Escherichia coli is inhibited in vitro by addition of preparations of elongation factor Ts purified to homogeneity. The inhibitory activity of elongation factor Ts on the RNA polymerase activity and the enzymatic activity of elongation factor Ts show the same temperature sensitivity. The extent of inhibition is strongly dependent on the template used for transcription. A mechanism for the control of RNA synthesis in vivo based on this inhibition found in vitro is proposed.


Assuntos
RNA Polimerases Dirigidas por DNA/antagonistas & inibidores , Escherichia coli/metabolismo , Fatores de Alongamento de Peptídeos/farmacologia , Precipitação Química , Escherichia coli/enzimologia , Guanosina Pentafosfato/farmacologia , Ligação Proteica
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