Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study).

Suspected deep vein thrombosis (DVT) is a common problem facing emergency physicians. Timely diagnostic testing must be performed to accurately identify patients with DVT. The purpose of this study was to evaluate the safety and effectiveness of a management strategy that combined consideration of clinical pretest probability and a d-dimer test to evaluate patients presenting to the emergency department with suspected deep vein thrombosis (DVT). A prospective cohort study was performed in the emergency departments of four tertiary care institutions involving 1075 patients with suspected DVT. An emergency physician determined the pretest probability for DVT to be low, moderate, or high using an explicit clinical model. A blood sample was taken for d-dimer testing. Subsequent investigations (compression ultrasound, venography) were performed based upon the pretest probability and the d-dimer result. Patients considered at low pretest probability with negative d-dimer had no further diagnostic testing performed. All patients in whom the diagnosis of DVT was excluded by the algorithm did not receive anticoagulant therapy and were followed up for 90 days for the development of proximal DVT or pulmonary embolism. Overall, 195 (18.1%; 95% CI 15.9% to 20.6%) of 1075 patients were confirmed to have proximal DVT. Of the 882 patients who had proximal DVT excluded during the initial evaluation period using the algorithms, four (0.5%; 95% CI 0.1% to 1.2%) were subsequently diagnosed with proximal DVT in the follow-up period, including three patients in the low pretest probability group (1.0%; 95% CI 0.2% to 2.1%) who had normal d-dimer and no additional diagnostic testing performed. None of the 882 patients (0%: 95% CI 0% to 0.5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting.

Computed tomographic evaluation of the normal adult odontoid. Implications for internal fixation.

STUDY DESIGN: Computed tomography scans of the dens were performed on patients who had no atlantoaxial pathology. OBJECTIVES: To determine whether one or two screws is optimal for fracture fixation and whether two screws can always negotiate the intramedullary odontoid cavity. SUMMARY OF BACKGROUND DATA: Fixation of Type II dens fractures traditionally has used C1-C2 posterior wiring and fusion. Two screws placed across an odontoid fracture as a method of rigid internal fixation also has been described. However, it is not known whether two screws can always negotiate the odontoid canal. METHODS: Ninety-two consecutive computerized tomography scans of the dens were performed on adults who had no atlantoaxial pathology. Measurements were taken from the scan and compared with the cross-sectional diameter of two odontoid screws. RESULTS: The critical diameter for the placement of two 3.5-mm cortical screws with tapping was 9.0 mm. This dimension was present in 95% of the patients studied. CONCLUSIONS: Correct orientation of the computerized tomography scanner is critical for accurate measurements. Two 3.5-mm screws can be used in internal fixation of Type II dens fractures in 95% of the patients if the inner cortex is tapped.

The role of the lumbar facet joints in spinal stability. Identification of alternative paths of loading.

STUDY DESIGN: The role of the facet joints in spinal stability was analyzed using long-segment cadaver spines. OBJECTIVES: To establish the existence of alternate paths of loading when the facet joints and anulus are compromised. SUMMARY OF BACKGROUND DATA: It has been reported that facet arthrosis and degeneration never occur without the presence of adjacent disc degeneration. This suggests that intact discs protect the facets from severe loading and degeneration. Based on these studies of spinal mechanics, the authors devised an experiment to further explain the relationship of the disc and the facet in sharing compressive loads. METHODS: Ten human cadaver spines were placed unsupported in an Instron Model 4206 Tensile Testing Machine. Compressive loads of 1000 N then were applied to the specimens at a rate of 20 N per minute. The facet joints, anterior anulus, and lateral anulus then were destroyed sequentially at L3 and the loading cycles were repeated. The load-deflection curves for each cycle were evaluated and compared with the intact specimen. RESULTS: Unilateral and bilateral facetectomies had little affect on the ability of the specimen to support a physiologic load. Facetectomies in combination with anterior anulus destruction showed a significant change in the ability of the specimen to support a load with an extension moment applied. CONCLUSIONS: The facet joints of the lumbar spine are not the principle support structures in extension. With destruction of the facets, an alternate path of loading is established. The alternate path of loading transfers axial loads to the anulus and anterior longitudinal ligament to support the spine. Although facet joint destruction will not produce acute instability, it will transfer the loads to the adjacent disc and conceivably accelerate its degeneration.