[Use of the modified Warthin-Starry method in pigmented nevi of the skin]. / Primena modifikovane Warthin-Starryjeve metode kod pigmentnih nevusa koze.

Warthin-Starry method is an argyrophilic method, performed at ph 3.2. It is a very efficient method for demonstration of melanin pigment granules in the nevus tissue and in malignant melanoma. We have concluded that it is highly specific for demonstration of melanin pigment granules, and more efficient than the Fontan-Masson method. The Fontan-Mason method reduces other pigments in the cell, apart from melanin. Modified Warthin-Starry method at ph 3.2 in the nevus tissue reduces only melanin pigment granules.

[Ultrastructure of pigmented skin nevi]. / Ultrastruktura pigmentnih nevusa koze.

Nevus cells are biologically significant because they are associated with epidermal melanocytes, while their clinical malignant melanomas. Apart from many other ultrastructural features their mutual characteristic is that they are exceptionally diverged. The main feature distinguishing nevus cells from melanocytes is the presence of big binuclear cells as well as frequent occurrence of grouped melanosomes in their cytoplasm.